Publications

    All Publications (242)

    Heat stress sensitizes zebrafish embryos to neurological and cardiac toxicity 
    Anna-Mari Haapanen-Saaristo et al. Biochem Biophys Res Commun. 2024 Nov 12;733:150682. doi: 10.1016/j.bbrc.2024.150682. Epub 2024 Sep 10. Published September 14, 2024
    Global warming increases the risk of dangerous heat waves, which may have deleterious effects on humans and wildlife. Here, we have utilized zebrafish embryos as...
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    SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers 
    Johanna Lilja et al. Nat Commun. 2024 Sep 12;15(1):8002. doi: 10.1038/s41467-024-52326-1. Published September 12, 2024
    The KRAS oncogene drives many common and highly fatal malignancies. These include pancreatic, lung, and colorectal cancer, where various activating KRAS mutations have made the...
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    Phenotypic profiling of human induced regulatory T cells at early differentiation: insights into distinct immunosuppressive potential 
    Roosa Kattelus et al. Cell Mol Life Sci. 2024 Sep 12;81(1):399. doi: 10.1007/s00018-024-05429-3. Published September 12, 2024
    Regulatory T cells (Tregs) play a key role in suppressing systemic effector immune responses, thereby preventing autoimmune diseases but also potentially contributing to tumor progression....
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    Comparative proteomics analysis of the mouse mini-gut organoid: insights into markers of gluten challenge from celiac disease intestinal biopsies 
    Robert Moulder et al. Front Mol Biosci. 2024 Aug 28;11:1446822. doi: 10.3389/fmolb.2024.1446822. eCollection 2024. Published September 12, 2024
    INTRODUCTION: Organoid models enable three-dimensional representation of cellular systems, providing flexible and accessible research tools, and can highlight key biomolecules. Such models of the intestinal...
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    Hypoxia and Foxn1 alter the proteomic signature of dermal fibroblasts to redirect scarless wound healing to scar-forming skin wound healing in Foxn1-/- mice 
    Barbara Gawronska-Kozak et al. BMC Biol. 2024 Sep 11;22(1):193. doi: 10.1186/s12915-024-01990-2. Published September 10, 2024
    CONCLUSIONS: The present data highlight the effect of hypoxia and Foxn1 on the protein profile and functionality of regenerative Foxn1^(-/-) DFs and demonstrate that the...
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    Serum lipidome associates with neuroimaging features in patients with traumatic brain injury 
    Ilias Thomas et al. iScience. 2024 Aug 3;27(9):110654. doi: 10.1016/j.isci.2024.110654. eCollection 2024 Sep 20. Published September 10, 2024
    Acute traumatic brain injury (TBI) is associated with substantial abnormalities in lipid biology, including changes in the structural lipids that are present in the myelin...
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    Disruption of HSD17B12 in mouse hepatocytes leads to reduced body weight and defect in the lipid droplet expansion associated with microvesicular steatosis 
    Hanna Heikelä et al. FASEB J. 2024 Sep 15;38(17):e70034. doi: 10.1096/fj.202400333RR. Published September 9, 2024
    The function of hydroxysteroid dehydrogenase 12 (HSD17B12) in lipid metabolism is poorly understood. To study this further, we created mice with hepatocyte-specific knockout of HSD17B12...
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    Lower Plasma Levels of Selective VGF (Non-Acronymic) Peptides in Bipolar Disorder: Comparative Analysis Reveals Distinct Patterns across Mood Disorders and Healthy Controls 
    Cristina Cocco et al. Neuropsychobiology. 2024;83(3-4):160-169. doi: 10.1159/000540673. Epub 2024 Sep 6. Published September 8, 2024
    CONCLUSION: Our findings suggest that lower plasma levels of NAPP and AQEE are specifically associated with BD, thus possibly representing a diagnostic biomarker in mood...
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    ECCB2024: The 23rd European Conference on Computational Biology 
    Anu Kukkonen-Macchi et al. Bioinformatics. 2024 Sep 1;40(Suppl 2):ii1-ii3. doi: 10.1093/bioinformatics/btae422. Published September 4, 2024
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    Intermediate filaments at a glance 
    Leila S Coelho-Rato et al. J Cell Sci. 2024 Aug 15;137(16):jcs261386. doi: 10.1242/jcs.261386. Epub 2024 Aug 29. Published August 29, 2024
    Intermediate filaments (IFs) comprise a large family of versatile cytoskeletal proteins, divided into six subtypes with tissue-specific expression patterns. IFs have a wide repertoire of...
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    Emerging ctDNA detection strategies in clinical cancer theranostics 
    Kexin Yi et al. Smart Med. 2023 Nov 13;2(4):e20230031. doi: 10.1002/SMMD.20230031. eCollection 2023 Nov. Published August 27, 2024
    Circulating tumor DNA (ctDNA) is naked DNA molecules shed from the tumor cells into the peripheral blood circulation. They contain tumor-specific gene mutations and other...
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    Iron-doped nanozymes with spontaneous peroxidase-mimic activity as a promising antibacterial therapy for bacterial keratitis 
    Xiwen Geng et al. Smart Med. 2024 May 22;3(2):e20240004. doi: 10.1002/SMMD.20240004. eCollection 2024 Jun. Published August 27, 2024
    The development of non-antibiotic pharmaceuticals with biocompatible and efficient antibacterial properties is of great significance for the treatment of bacterial keratitis. In this study, we...
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