Trajectories of microbiome-derived bile acids in early life – insights into the progression to islet autoimmunity
medRxiv [Preprint]. 2025 Feb 24:2025.02.18.25322275. doi: 10.1101/2025.02.18.25322275.
Published on March 10, 2025
ABSTRACT
Recent studies reveal that gut microbes produce diverse bile acid conjugates, termed microbially conjugated bile acids (MCBAs). However, their regulation and health effects remain unclear. Here, we analyzed early-life MCBA patterns and their link to islet autoimmunity. We quantified 110 MCBAs in 303 stool samples collected longitudinally (3-36 months) from children who developed one or more islet autoantibodies and controls who remained autoantibody-negative. Stool MCBAs showed distinct age-dependent trajectories and correlated with gut microbiome composition. Altered levels of ursodeoxycholic and deoxycholic acid conjugates were linked to islet autoimmunity as well as modulated monocyte activation in response to immunostimulatory lipopolysaccharide and Th17/Treg cell balance. These findings suggest MCBAs influence immune development and type 1 diabetes risk.
PMID:40061321 | PMC:PMC11888530 | DOI:10.1101/2025.02.18.25322275
Latest Publications
- Author response to “Commentary on detoxification of deoxynivalenol by pathogen-inducible tau-class glutathione transferases from wheat” by Dr. Latika Shendre
- Editorial: Epigenetic regulation of T cell function in type 1 diabetes
- Prenatal exposure to persistent organic pollutants modulates the metabolism and gut microbiota of the offspring
- Preventing Proteomics Data Tombs Through Collective Responsibility and Community Engagement
- Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells