Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants that can disrupt human hepatic metabolism both directly and through alterations of the gut microbiota. However, the contribution of microbiota-mediated mechanisms…
In Situ Biomineralization Enhances Mitochondrial Transplantation to Differentiating Osteoclast Precursors for Suppressing Cancer-Induced Osteolysis
Cancer-induced bone osteolysis is a common complication of multiple malignancies and may actively contribute to bone metastasis. Its core pathology is closely associated with mitochondrial metabolic dysfunction during osteoclast differentiation.
Proteomic insights into human induced regulatory T cells: the role of LPXN and CD160 in immune suppression
Regulatory T cells (Treg) play a central role in maintaining immune homeostasis, and the implementation of in vitro induced Treg cells (iTreg) to control immune function has significant potential in…
NucleiSky enables cross-scale multimodal registration of microscopy data using nuclei constellations
Integrating tissue-level organisation with sub-cellular resolution and molecular information often requires combining multiple microscopy modalities and scales. However, aligning images acquired with different modalities, settings, or instruments remains challenging. Here,…
Performance of a next-generation rapid lipoarabinomannan urine assay for tuberculosis in outpatients with and without HIV in South Africa and Uganda: a two-centre diagnostic accuracy study
BACKGROUND: Non-sputum-based tuberculosis tests are a global priority because sputum-dependent diagnostics systematically miss populations at highest risk of disease, including people living with HIV. We evaluated the diagnostic accuracy of…
Using NIR-emitting MgO:Li,Ce,Sm microparticles in the preparation of biophotonic glass – a promising approach to enable optical NIR imaging
One significant challenge in working with reconstructive bioactive glass implants is the difficulty in postoperative imaging, due to their density being very similar to that of bone. One possibility to…
Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish
Biotin is a vital cofactor in cellular carboxylation reactions and avidins are biotin-binding proteins that are produced by bacteria and fungi but also by egg-laying vertebrates, including avian species and…
Unbiased discovery of autoreactive type 1 diabetes T-cell receptors that bind specific hybrid insulin peptides
While recent studies have revealed much about the pathogenesis of type 1 diabetes (T1D), the self-antigens and immune receptors that drive cellular autoimmunity have not been precisely determined. In this…
Nutrient intake, gut inflammation markers, and intestinal permeability in infants aged 6-12 months
CONCLUSION: While breastfeeding remains a major determinant of gut maturation, consumption of complementary foods higher in intercorrelated nutrients including dietary fibre and potassium is associated with lower gut inflammation markers…