CONCLUSIONS: These findings demonstrate SAT and VAT remodeling in obesity and show that MBS partially reverses transcriptional changes in SAT, providing mechanistic insight into its metabolic benefits. They also highlight…
Ultra-stable Zn/Fe bimetallic DNA nanonetworks enable glucose-deprivation-sensitized ferroptosis for gastric cancer therapy
Metal-coordinated DNA nanostructures have emerged as promising drug delivery platforms owing to their rapid synthesis and high loading capacity. However, current systems degrade within two weeks, presumably because uniform coordination…
From gut to lung: Microbiota-derived metabolites reshaping the tumor immune microenvironment
No abstract…
Fast and slow gene expression changes in blood following acute social stress
Social stress is a risk factor for psychiatric disorders and also influences immune function. While it is known that acute social stress impacts the number of immune cells in circulation,…
A candidate CD4⁺ T-cell gene expression panel for multiple sclerosis highlights MgADP-associated genes
Multiple sclerosis (MS) is an autoimmune disease characterized by immune cell dysregulation. HLA class II alleles drive the disease risk, thereby highlighting CD4^(+) T cells as central contributors to MS…
Asymmetric Structure-Driven Functional Synergy: A Multistimuli-Activated Janus Nanomotor for Self-Amplifying NO Cascade Therapy
Nitric oxide (NO)-based cancer therapy is fundamentally limited by poor intratumoral penetration of exogenous donors and their inability to sustain localized relevant flux. Here, a multistimuli-activated Janus nanomotor was developed…
Metabolic modeling with reverse mapping links host perturbations to Mycobacterium tuberculosis
Understanding host-pathogen interactions during Mycobacterium tuberculosis (Mtb) infection has largely relied on identifying bacterial genes essential for intracellular survival. However, conventional reverse genetics approaches often overlook host pathways that regulate…
Long-term recovery and microbiota-gut-brain axis disruption after traumatic brain injury (OVERCOME-TBI): protocol for a prospective, observational clinical study
INTRODUCTION: Traumatic brain injury (TBI) is a major cause of long-term disability worldwide, but the pathophysiological mechanisms underlying its chronic sequelae remain incompletely understood. In addition to persistent neuroinflammation, evidence…
Prenatal Exposure to Persistent Organic Pollutants Is Associated with Altered Lipid and Metabolomic Profiles in Mothers and Newborns
Maternal exposure to persistent organic pollutants (POPs) has been linked with adverse pregnancy and birth outcomes, yet the underlying biological pathways involved remain poorly characterized. In this study, we examined…
Pharmacokinetics and efficacy of tank water-administered BRAF-inhibitor dabrafenib in a zebrafish melanoma model
Zebrafish models are widely used to study BRAF-mutant melanoma biology. However, long-term treatment of adult fish with small molecule BRAF inhibitors remains challenging, and pharmacokinetic data to inform rational dosing…