Current methodologies for detecting the sequence of double-stranded DNA (dsDNA) require amplifying and denaturing the target into single-stranded DNA (ssDNA) to enable sequence detection through Watson-Crick base pairing. However, these…
Prenatal exposure to persistent organic pollutants modulates the metabolism and gut microbiota of the offspring
Emerging evidence suggests that environmental contaminants can influence both human metabolism and gut microbiota composition. However, the specific effects of prenatal exposure to persistent organic pollutants (POPs) on host-microbiome metabolic…
Preventing Proteomics Data Tombs Through Collective Responsibility and Community Engagement
Public proteomics repositories now host vast amounts of mass spectrometry data, yet much of it remains difficult to reuse, risking “data tombs” that are open access but not practically re-analyzable.
Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells
Metastases arise from a multistep process during which tumour cells face several microenvironmental mechanical challenges, which influence metastatic success. However, how circulating tumour cells (CTCs) adapt their mechanics to such…
Progressive fibrosis in human MASLD is associated with spatially linked transcriptomic signatures of metabolic reprogramming and senescence
CONCLUSIONS: Taken together, our valuable discovery dataset highlights the complex crosstalk between metabolic perturbations and inflammation underpinning fibrosis progression in MASLD.
Turku Bioscience Centre Is Recruiting New Research Leaders
Turku Bioscience Centre is currently inviting applications for two key research positions that will strengthen its internationally competitive bioscience research environment in Turku, Finland. We are seeking a…
The inflammatory path toward type 1 diabetes begins during pregnancy
Type 1 diabetes (T1D) is increasing globally, yet the earliest biological determinants remain poorly defined, particularly in general population studies. We studied the Swedish population-based ABIS birth cohort (n =…
Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers
The rapid, transient, and unpredictable nature of interactions between circulating cells and the endothelium challenges the investigation of these events under flow conditions. Here, we developed an imaging and image-analysis…