c-Jun N-terminal kinases (JNKs) are implicated in both neurodegeneration and mood regulation, including anxiety and depressive-like behaviours. Yet the consequences of JNK inhibition in vivo on protein phosphorylation in the…
Disrupting Complement-Inflammation Positive Feedback Circuit via Oligonucleotide Hydrogel Microspheres for Reversing Joint Inflammation
The positive feedback circuit between the complement system and inflammatory immune responses maps the malignant progression of chronic joint inflammation. Prolonged dysregulation of the immune microenvironment in rheumatoid arthritis (RA)…
Vimentin in the tumor microenvironment: orchestrating invasion, immunity, and metabolism
Vimentin, a type III intermediate filament protein, has gained recognition as a multifunctional regulator within the tumor microenvironment (TME). While traditionally considered a hallmark of epithelial-to-mesenchymal transition (EMT), vimentin is…
Structural and functional characterization of a metagenomically derived γ-type carbonic anhydrase and its engineering into a hyperthermostable esterase
The 16S microbial community profiling of a metagenomics library from geothermal spring at Lisvori (Lesvos island, Greece) enabled the identification of a putative sequence exhibiting 95% identity to the γ-type…
Calponin isoforms define the cell-type-specific organization and dynamics of actomyosin bundles
Contractile actomyosin bundles, stress fibers, are important for cell migration, adhesion, morphogenesis, and mechanosensing. Calponin (CNN) family proteins are abundant stress fiber components, but their cellular functions and isoform-specific roles…
Dynamics of gut metabolome and microbiota maturation during early life
Early-life gut microbiome-metabolome crosstalk plays a crucial role in maintaining host physiology. The microbially produced metabolites often convey effects on host health and physiology. This study investigates the gut metabolites,…
Complement components C1r and C1s promote oral squamous cell carcinoma cell proliferation
CONCLUSIONS: The complement system may be a common molecular mechanism for OSCC tumorigenesis, which arises from different origins: odontogenic and mucosal epithelium. Elevated C1r/C1s expression contributes to OSCC cell proliferation.
Hepatic zonation determines tumorigenic potential of mutant β-catenin
Oncogenic mutations in phenotypically normal tissue are common across adult organs^(1,2). This suggests that multiple events need to converge to drive tumorigenesis and that many processes such as tissue differentiation…
LINC01871 is exclusively expressed in T and NK cells and is highly induced upon CD4+ T cell activation
Long intergenic noncoding RNAs (lincRNAs) regulate biological processes in health and disease. Recent findings highlight the importance of lincRNAs in regulating T cell development and function. Here, we identified a…
Breast cancer remodels lymphatics in sentinel lymph nodes
Cancer metastasis to sentinel lymph nodes (LNs) is often the first marker of potential disease progression. Although it is recognized that tumor-induced lymphangiogenesis facilitates metastasis into LNs in murine models,…