Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells

    Carl-Gustaf A. Stenvall, Joel H. Nyström, Ciarán Butler-Hallissey, Theresia Jansson, Taina R. H. Heikkilä, Stephen A. Adam, Roland Foisner, Robert D. Goldman, Karen M. Ridge, Diana M. Toivola

    Molecular Biology of the Cell (2022)

    Published on December 3, 2025

    DOI: https://doi.org/10.1091/mbc.e20-06-0387

    Core: Genome Editing Core

    Abstract

    Cytoplasmic keratins couple with SUN2 and lamin A at the nuclear envelope and maintain plectin, LINC complex, lamin and lamin-associated protein levels in colonic epithelial cells. Loss of keratin 8 has no major impact on nuclear shape and size, but compromises nuclear envelope integrity basally and during shear stress.
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