The SIMPLIFY Protocol: A Monophasic Extraction System Suitable for Exposomics, Metabolomics, Lipidomics, and Proteomics Research

    Anh Hoang Nguyen, Victor Castro-Alves, Emilia Holmström Flores, João Marcos G. Barbosa, Matilda Kråkström, Päivikki Reinivuori, Otto Kauko, Alex Dickens, Matej Orešič, Tuulia Hyötyläinen

    Analytical Chemistry (2025)

    Published on November 12, 2026

    DOI: https://doi.org/10.1021/acs.analchem.5c05322

    Core: Metabolomics
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    Staphylococcus aureus Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma
    M. Gluud et al. • 2026 • Allergy
    ABSTRACT Background Skin barrier dysfunction is central to inflammation and susceptibility to infection in atopic dermatitis (AD). Cutaneous T‐cell lymphoma...
    Core:Cytometry Core
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    Atorvastatin regulates hepatic transcriptome PXR dependently but distinct from pregnenolone 16α-carbonitrile and does not induce PXR-mediated liver steatosis
    H. Nabil et al. • 2026 • Archives of Toxicology
    Core:Finnish Functional Genomics Centre
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    Cohort Profile Update: Expanding the Cardiovascular Risk in Young Finns Study into a multigenerational cohort
    K. Pahkala et al. • 2026 • International Journal of Epidemiology
    Core:Finnish Functional Genomics Centre
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    Dynamic landscape of transcription initiation by yeast RNA polymerase I
    O. Parilova et al. • 2026 • Nucleic Acids Research
    Abstract RNA polymerase I (Pol I) synthesizes precursor ribosomal RNA, a key step in ribosome biogenesis. Elevated Pol I activity...
    Core:Protein Structure and Chemistry
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    Emerging Microbial Lipid Shifts in a Multistage Simulated Gut Inoculated with Human Fecal Microbiota
    I. Tamanna et al. • 2026 • Journal of Proteome Research
    Abstract Food residues that bypass human digestion are further digested by gut microbes, leading to the production of diverse metabolites,...
    Core:Metabolomics
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