Publications

    PUBLICATION

    Protocol to study early lung developmental branching in mouse embryos using explant culture 

    Salli Talvi et al.

    STAR Protoc. 2024 Sep 20;5(3):103198. doi: 10.1016/j.xpro.2024.103198. Epub 2024 Jul 17.

    Published on July 18, 2024

    Mouse lung branching morphogenesis creates epithelial tree structures required for respiration. Here, we present a protocol for studying mouse lung developmental branching using lung explant Read more

    PUBLICATION

    TLNRD1 is a CCM complex component and regulates endothelial barrier integrity 

    Neil J Ball et al.

    J Cell Biol. 2024 Sep 2;223(9):e202310030. doi: 10.1083/jcb.202310030. Epub 2024 Jul 16.

    Published on July 16, 2024

    We previously identified talin rod domain-containing protein 1 (TLNRD1) as a potent actin-bundling protein in vitro. Here, we report that TLNRD1 is expressed in the Read more

    PUBLICATION

    Identification of an H-Ras nanocluster disrupting peptide 

    Candy Laura Steffen et al.

    Commun Biol. 2024 Jul 9;7(1):837. doi: 10.1038/s42003-024-06523-9.

    Published on July 9, 2024

    Hyperactive Ras signalling is found in most cancers. Ras proteins are only active in membrane nanoclusters, which are therefore potential drug targets. We previously showed Read more

    PUBLICATION

    Body-wide genetic deficiency of poly(ADP-ribose) polymerase 14 sensitizes mice to colitis 

    Madhukar Vedantham et al.

    FASEB J. 2024 Jul 15;38(13):e23775. doi: 10.1096/fj.202400484R.

    Published on July 5, 2024

    Inflammatory bowel disease (IBD) is a chronic disease of the gastrointestinal tract affecting millions of people. Here, we investigated the expression and functions of poly(ADP-ribose) Read more

    PUBLICATION

    Multi-omics analysis reveals drivers of loss of β-cell function after newly diagnosed autoimmune type 1 diabetes: An INNODIA multicenter study 

    Jose Juan Almagro Armenteros et al.

    Diabetes Metab Res Rev. 2024 Jul;40(5):e3833. doi: 10.1002/dmrr.3833.

    Published on July 4, 2024

    CONCLUSIONS: Features that differ between individuals with slow and rapid decline in β-cell mass could be valuable in staging and prediction of the rate of Read more

    PUBLICATION

    Cancer cell invasion alters the protein profile of extracellular vesicles 

    Jens C Luoto et al.

    J Extracell Biol. 2023 Nov 27;2(12):e124. doi: 10.1002/jex2.124. eCollection 2023 Dec.

    Published on June 28, 2024

    Extracellular vesicles (EVs) are important mediators of intercellular communication involved in local and long-range signalling of cancer metastasis. The onset of invasion is the key Read more

    PUBLICATION

    SNM1A is crucial for efficient repair of complex DNA breaks in human cells 

    Lonnie P Swift et al.

    Nat Commun. 2024 Jun 25;15(1):5392. doi: 10.1038/s41467-024-49583-5.

    Published on June 25, 2024

    DNA double-strand breaks (DSBs), such as those produced by radiation and radiomimetics, are amongst the most toxic forms of cellular damage, in part because they Read more

    PUBLICATION

    Wnt/β-catenin-YAP axis in the pathogenesis of primary intraosseous carcinoma NOS, deriving from odontogenic keratocyst 

    Yusuke Nakako et al.

    Pathol Res Pract. 2024 Aug;260:155420. doi: 10.1016/j.prp.2024.155420. Epub 2024 Jun 20.

    Published on June 22, 2024

    Odontogenic tumors (OGTs), which originate from cells of odontogenic apparatus and their remnants, are rare entities. Primary intraosseous carcinoma NOS (PIOC), is one of the Read more

    PUBLICATION

    DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer 

    Majid Momeny et al.

    EMBO Mol Med. 2024 Jul;16(7):1603-1629. doi: 10.1038/s44321-024-00088-0. Epub 2024 Jun 17.

    Published on June 17, 2024

    Despite clinical benefits of tyrosine kinase inhibitors (TKIs) in cancer, most tumors can reactivate proliferation under TKI therapy. Here we present transcriptional profiling of HER2+ Read more

    PUBLICATION

    Serum proteomics of mother-infant dyads carrying HLA-conferred type 1 diabetes risk 

    Santosh D Bhosale et al.

    iScience. 2024 May 22;27(6):110048. doi: 10.1016/j.isci.2024.110048. eCollection 2024 Jun 21.

    Published on June 17, 2024

    In-utero and dietary factors make important contributions toward health and development in early childhood. In this respect, serum proteomics of maturing infants can provide insights Read more

    PUBLICATION

    Improved breast milk proteome coverage by DIA based LC-MS/MS method 

    Jenni Viitaharju et al.

    Proteomics. 2024 Jul;24(14):e2300340. doi: 10.1002/pmic.202300340. Epub 2024 Jun 14.

    Published on June 14, 2024

    The breast milk composition includes a multitude of bioactive factors such as viable cells, lipids and proteins. Measuring the levels of specific proteins in breast Read more

    PUBLICATION

    Indignity of Nazi data: reflections on the utilization of illicit research 

    Iman Farahani et al.

    Med Health Care Philos. 2024 Sep;27(3):381-387. doi: 10.1007/s11019-024-10212-z. Epub 2024 Jun 6.

    Published on June 6, 2024

    Human rights may feel self-apparent to us, but less than 80 years ago, one of the most advanced countries at the time acted based on Read more