Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive function of human CD4+ regulatory T cells by regulating IL2RA 

Syed Bilal Ahmad Andrabi et al.

Proc Natl Acad Sci U S A. 2024 Jun 4;121(23):e2315363121. doi: 10.1073/pnas.2315363121. Epub 2024 May 28.

Published on May 28, 2024

Regulatory T cells (Tregs) are central in controlling immune responses, and dysregulation of their function can lead to autoimmune disorders or cancer. Despite extensive studies Read more

A proximal enhancer regulates RORA expression during early human Th17 cell differentiation 

Ubaid Ullah Kalim et al.

Clin Immunol. 2024 Jul;264:110261. doi: 10.1016/j.clim.2024.110261. Epub 2024 May 22.

Published on May 24, 2024

Gene regulatory elements, such as enhancers, greatly influence cell identity by tuning the transcriptional activity of specific cell types. Dynamics of enhancer landscape during early Read more

Comparative Metabolomics and Microbiome Analysis of Ethanol versus OMNImet/gene•GUT Fecal Stabilization 

Heidi Isokääntä et al.

Anal Chem. 2024 Jun 4;96(22):8893-8904. doi: 10.1021/acs.analchem.3c04436. Epub 2024 May 23.

Published on May 23, 2024

Metabolites from feces provide important insights into the functionality of the gut microbiome. As immediate freezing is not always feasible in gut microbiome studies, there Read more

Serum hydroxysteroid (17beta) dehydrogenase 1 concentration in pregnant women correlates with pregnancy-associated plasma protein A but does not serve as an independent marker for preeclampsia† 

Taija Heinosalo et al.

Biol Reprod. 2024 Aug 15;111(2):436-447. doi: 10.1093/biolre/ioae078.

Published on May 23, 2024

Hydroxysteroid (17beta) dehydrogenase 1 (HSD17B1) is a steroid synthetic enzyme expressed in ovarian granulosa cells and placental syncytiotrophoblasts. Here, HSD17B1 serum concentration was measured with Read more