Kevin Daupin et al.Cell Stress Chaperones. 2025 May 1:100079. doi: 10.1016/j.cstres.2025.100079. Online ahead of print.Published May 3, 2025
Heat shock transcription factors 1 and 2 (HSF1 and HSF2) are the major regulators of the cellular response to stressors, notably to heat shock and... Read more
Maria K Jaakkola et al.Sci Rep. 2025 May 2;15(1):15393. doi: 10.1038/s41598-025-98492-0.Published May 2, 2025
Pathway analysis is a frequent step in studies involving gene or protein expression data, but most of the available pathway methods are designed for simple... Read more
Emil Hiitola et al.Sci Adv. 2025 May 2;11(18):eadt9846. doi: 10.1126/sciadv.adt9846. Epub 2025 Apr 30.Published April 30, 2025
Clonal hematopoiesis (CH) becomes more prevalent with aging and may influence inflammatory diseases by altering immune function. While CH of indeterminate potential (CHIP) promotes inflammation... Read more
Erica Routila et al.Cancer Med. 2025 May;14(9):e70717. doi: 10.1002/cam4.70717.Published April 27, 2025
CONCLUSIONS: We demonstrate that while integrin glycovariants are abundant in HNSCC tumors and ITGB1-WFL was associated with invasiveness, integrin glycovariants do not directly correlate with... Read more
Rayan Nikkilä et al.Head Neck Pathol. 2025 Apr 25;19(1):45. doi: 10.1007/s12105-025-01784-0.Published April 25, 2025
CONCLUSION: The GWAS detected two novel genetic associations with OTSCC. Further research is needed to identify the genes at these loci that contribute to the... Read more
Lorenza Cutrone et al.PLoS Pathog. 2025 Apr 17;21(4):e1013108. doi: 10.1371/journal.ppat.1013108. eCollection 2025 Apr.Published April 17, 2025
The Human gamma-herpesviruses Kaposi's sarcoma herpesvirus (KSHV) and Epstein-Barr virus (EBV) are causally associated to a wide range of cancers. While the default infection program... Read more
Neeraj Prabhakar et al.Small Sci. 2024 Jul 8;4(9):2400084. doi: 10.1002/smsc.202400084. eCollection 2024 Sep.Published April 11, 2025
Mesoporous silica nanoparticles (MSNs) have emerged as promising drug carriers that can facilitate targeted anticancer drug delivery, but efficiency studies relying on active targeting mechanisms... Read more
Michalis Gounis et al.Dev Cell. 2025 Apr 7;60(7):979-981. doi: 10.1016/j.devcel.2025.03.006.Published April 8, 2025
The PI3K/AKT/mTOR pathway is considered a key therapeutic target in triple-negative breast cancer (TNBC). In this issue of Developmental Cell, Remy et al. challenge this... Read more
Joanna W Pylvänäinen et al.J Cell Sci. 2025 Apr 1;138(7):jcs263801. doi: 10.1242/jcs.263801. Epub 2025 Apr 7.Published April 7, 2025
Data exploration is an essential step in quantitative cell biology, bridging raw data and scientific insights. Unlike polished, published figures, effective data exploration requires a... Read more
Pengzhen Zhuang et al.Bioact Mater. 2025 Mar 15;49:399-417. doi: 10.1016/j.bioactmat.2025.03.008. eCollection 2025 Jul.Published March 27, 2025
The alterations in glucose metabolism flux induced by mitochondrial function changes are crucial for regulating bone immune homeostasis. The restoration of mitochondrial homeostasis, serving as... Read more
Gautier Follain et al.Mol Oncol. 2025 Mar 24. doi: 10.1002/1878-0261.70025. Online ahead of print.Published March 24, 2025
Cancer's notorious heterogeneity poses significant challenges, as each tumor comprises a unique ecosystem. While single-cell and spatial transcriptomics advancements have transformed our understanding of spatial... Read more
