Publications

    Publication
    Empagliflozin attenuates hypoxia-induced heart failure of zebrafish embryos via influencing MMP13 expression 
    R Huttunen et al. Biomed Pharmacother. 2024 Nov;180:117453. doi: 10.1016/j.biopha.2024.117453. Epub 2024 Sep 26. Published September 27, 2024
    CONCLUSIONS: Our study shows that empagliflozin´s favorable effect on attenuating HF is mediated via MMP13. MMP13 provides a novel option when developing new therapeutics for... Read more
    Publication
    IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis 
    Peng Zhang et al. Cell Metab. 2024 Oct 1;36(10):2341-2354.e6. doi: 10.1016/j.cmet.2024.08.012. Epub 2024 Sep 23. Published September 24, 2024
    The exponential rise in metabolic dysfunction-associated steatotic liver disease (MASLD) parallels the ever-increasing consumption of energy-dense diets, underscoring the need for effective MASLD-resolving drugs. MASLD... Read more
    Publication
    Atomistic simulations reveal impacts of missense mutations on the structure and function of SynGAP1 
    Aliaa E Ali et al. Brief Bioinform. 2024 Sep 23;25(6):bbae458. doi: 10.1093/bib/bbae458. Published September 23, 2024
    De novo mutations in the synaptic GTPase activating protein (SynGAP) are associated with neurological disorders like intellectual disability, epilepsy, and autism. SynGAP is also implicated... Read more
    Publication
    Single-cell transcriptome analysis of the early immune response in the lymph nodes of Borrelia burgdorferi-infected mice 
    Varpu Rinne et al. Microbes Infect. 2025 Feb;27(2):105424. doi: 10.1016/j.micinf.2024.105424. Epub 2024 Sep 19. Published September 21, 2024
    Lyme borreliosis is a disease caused by Borrelia burgdorferi sensu lato bacteria. Borrelia burgdorferi is known to induce prolonged extrafollicular immune responses and abnormal germinal... Read more
    Publication
    Proteomic profiling identifies a direct interaction between heat shock transcription factor 2 and the focal adhesion adapter talin-1 
    Alejandro J Da Silva et al. FEBS J. 2024 Nov;291(21):4830-4848. doi: 10.1111/febs.17271. Epub 2024 Sep 16. Published September 17, 2024
    Heat shock factor 2 (HSF2) is a versatile transcription factor that regulates gene expression under stress conditions, during development, and in disease. Despite recent advances... Read more
    Publication
    Heat stress sensitizes zebrafish embryos to neurological and cardiac toxicity 
    Anna-Mari Haapanen-Saaristo et al. Biochem Biophys Res Commun. 2024 Nov 12;733:150682. doi: 10.1016/j.bbrc.2024.150682. Epub 2024 Sep 10. Published September 14, 2024
    Global warming increases the risk of dangerous heat waves, which may have deleterious effects on humans and wildlife. Here, we have utilized zebrafish embryos as... Read more
    Publication
    SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers 
    Johanna Lilja et al. Nat Commun. 2024 Sep 12;15(1):8002. doi: 10.1038/s41467-024-52326-1. Published September 12, 2024
    The KRAS oncogene drives many common and highly fatal malignancies. These include pancreatic, lung, and colorectal cancer, where various activating KRAS mutations have made the... Read more
    Publication
    Phenotypic profiling of human induced regulatory T cells at early differentiation: insights into distinct immunosuppressive potential 
    Roosa Kattelus et al. Cell Mol Life Sci. 2024 Sep 12;81(1):399. doi: 10.1007/s00018-024-05429-3. Published September 12, 2024
    Regulatory T cells (Tregs) play a key role in suppressing systemic effector immune responses, thereby preventing autoimmune diseases but also potentially contributing to tumor progression.... Read more
    Publication
    Comparative proteomics analysis of the mouse mini-gut organoid: insights into markers of gluten challenge from celiac disease intestinal biopsies 
    Robert Moulder et al. Front Mol Biosci. 2024 Aug 28;11:1446822. doi: 10.3389/fmolb.2024.1446822. eCollection 2024. Published September 12, 2024
    INTRODUCTION: Organoid models enable three-dimensional representation of cellular systems, providing flexible and accessible research tools, and can highlight key biomolecules. Such models of the intestinal... Read more
    Publication
    Hypoxia and Foxn1 alter the proteomic signature of dermal fibroblasts to redirect scarless wound healing to scar-forming skin wound healing in Foxn1-/- mice 
    Barbara Gawronska-Kozak et al. BMC Biol. 2024 Sep 11;22(1):193. doi: 10.1186/s12915-024-01990-2. Published September 10, 2024
    CONCLUSIONS: The present data highlight the effect of hypoxia and Foxn1 on the protein profile and functionality of regenerative Foxn1^(-/-) DFs and demonstrate that the... Read more
    Publication
    Serum lipidome associates with neuroimaging features in patients with traumatic brain injury 
    Ilias Thomas et al. iScience. 2024 Aug 3;27(9):110654. doi: 10.1016/j.isci.2024.110654. eCollection 2024 Sep 20. Published September 10, 2024
    Acute traumatic brain injury (TBI) is associated with substantial abnormalities in lipid biology, including changes in the structural lipids that are present in the myelin... Read more
    Publication
    Disruption of HSD17B12 in mouse hepatocytes leads to reduced body weight and defect in the lipid droplet expansion associated with microvesicular steatosis 
    Hanna Heikelä et al. FASEB J. 2024 Sep 15;38(17):e70034. doi: 10.1096/fj.202400333RR. Published September 9, 2024
    The function of hydroxysteroid dehydrogenase 12 (HSD17B12) in lipid metabolism is poorly understood. To study this further, we created mice with hepatocyte-specific knockout of HSD17B12... Read more
    Last updated on June 25, 2025