Adv Mater. 2024 May;36(19):e2310318. doi: 10.1002/adma.202310318. Epub 2024 Feb 20.Neutrophils are the most abundant white blood cells in the circulation and act as the first line of defense against infections. Increasing evidence suggests that neutrophils possess heterogeneous phenotypes and functional plasticity in human health and diseases, including cancer. Neutrophils play multifaceted roles in cancer development and progression, and an N1/N2 paradigm of neutrophils in cancer is proposed, where N1 neutrophils exert anti-tumor properties while N2 neutrophils display tumor-supportive and immune-suppressive functions. Selective activation of beneficial neutrophil population and targeted inhibition or re-polarization of tumor-promoting neutrophils has shown an important potential in tumor therapy. In addition, due to the natural inflammation-responsive and physical barrier-crossing abilities, neutrophils and their derivatives (membranes and extracellular vesicles (EVs)) are regarded as advanced drug delivery carriers for enhanced tumor targeting and improved therapeutic efficacy. In this review, the recent advances in engineering neutrophils for drug delivery and targeting neutrophils for remodeling tumor microenvironment (TME) are comprehensively presented. This review will provide a broad understanding of the potential of neutrophils in cancer therapy.Published December 10, 2024
Neutrophils are the most abundant white blood cells in the circulation and act as the first line of defense against infections. Increasing evidence suggests that... Read more
Cell Stress Chaperones. 2024 Feb;29(1):143-157. doi: 10.1016/j.cstres.2024.01.006. Epub 2024 Feb 3.Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. Sixty-one years after the discovery of the heat shock response by Ferruccio Ritossa, many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperones was reported at the 12th International Symposium on Heat Shock Proteins in Biology, Medicine and the Environment in the Old Town Alexandria, VA, USA from 28th to 31st of October 2023.Published December 10, 2024
Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms... Read more
iScience. 2024 Jan 15;27(2):108914. doi: 10.1016/j.isci.2024.108914. eCollection 2024 Feb 16.Embigin (Gp70), a receptor for fibronectin and an ancillary protein for monocarboxylate transporters, is known to regulate stem cell niches in sebaceous gland and bone marrow. Here, we show that embigin expression is at high level during early mouse embryogenesis and that embigin is essential for lung development. Markedly increased neonatal mortality of Emb-/- mice can be explained by the compromised lung maturation: in Emb-/- mice (E17.5) the number and the size of the small airways and distal airspace are significantly smaller, there are fewer ATI and ATII cells, and the alkaline phosphatase activity in amniotic fluid is lower. Emb-/- lungs show less peripheral branching already at E12.5, and embigin is highly expressed in lung primordium. Thus, embigin function is essential at early pseudoglandular stage or even earlier. Furthermore, our RNA-seq analysis and Ki67 staining results support the idea that the development of Emb-/- lungs is rather delayed than defected.Published December 10, 2024
Embigin (Gp70), a receptor for fibronectin and an ancillary protein for monocarboxylate transporters, is known to regulate stem cell niches in sebaceous gland and bone... Read more
Rawand A Mustaf et al.Adv Sci (Weinh). 2024 Nov 21:e2407067. doi: 10.1002/advs.202407067. Online ahead of print.Published November 22, 2024
Local intratympanic drug delivery to the inner ear possesses significant otological clinical promise as cisplatin-induced hearing loss (CIHL) therapy, inducing significantly less side effects than... Read more
Silvia Sabatini et al.Cell Rep Med. 2024 Nov 19;5(11):101820. doi: 10.1016/j.xcrm.2024.101820.Published November 20, 2024
Metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH) are associated with a high prevalence of type 2 diabetes (T2D). Individuals with MASLD exhibit insulin... Read more
Toni Laine et al.Chembiochem. 2025 Mar 15;26(6):e202400908. doi: 10.1002/cbic.202400908. Epub 2024 Nov 28.Published November 15, 2024
Molecular Spherical Nucleic Acids (MSNAs) are atomically uniform dendritic nanostructures and potential delivery vehicles for oligonucleotides. The radial formulation combined with covalent conjugation may hide... Read more
Annamaria Petrilla et al.Sci Rep. 2024 Nov 8;14(1):27179. doi: 10.1038/s41598-024-78102-1.Published November 8, 2024
Shotgun metabarcoding was conducted to examine the microbiota in a total of 48 samples from 12 critically ill patients, analyzing samples from both the oropharynx... Read more
Joshua Klein et al.Anal Chem. 2024 Nov 19;96(46):18491-18501. doi: 10.1021/acs.analchem.4c04091. Epub 2024 Nov 8.Published November 8, 2024
Mass spectral libraries are collections of reference spectra, usually associated with specific analytes from which the spectra were generated, that are used for further downstream... Read more
Sara Gracie et al.Am J Med Genet A. 2025 Mar;197(3):e63927. doi: 10.1002/ajmg.a.63927. Epub 2024 Nov 6.Published November 6, 2024
Heterozygous de novo loss of function variants in the motor domain of KIF5C are associated with a neurodevelopmental disorder characterized by infantile-onset epilepsy, frontal cortical... Read more
Abraham Kuri Cruz et al.Metabolomics. 2024 Nov 4;20(6):125. doi: 10.1007/s11306-024-02185-0.Published November 4, 2024
CONCLUSION: This collaborative exercise emphasized the broad chemical survey possible with multi-technique approaches. Community engagement is essential for the evaluation and characterization of common materials... Read more
Linda Nissi et al.Cancer Med. 2024 Nov;13(21):e70371. doi: 10.1002/cam4.70371.Published November 2, 2024
CONCLUSIONS: High xCT expression was associated with poor prognosis in OPSCC. Our findings suggest that joint analysis of xCT and p16 may add significant value... Read more
Afonso Mendes et al.Res Sq [Preprint]. 2024 Oct 15:rs.3.rs-5182329. doi: 10.21203/rs.3.rs-5182329/v1.Published November 1, 2024
From molecules to organelles, cells exhibit recurring structural motifs across multiple scales. Understanding these structures provides insights into their functional roles. While superresolution microscopy can... Read more
