Publications

    PUBLICATION

    Designing Fluorescent Estrogen Mimetic 7-hydroxycoumarin Probe Substrates for Human Sulfotransferase Enzymes 

    Risto O Juvonen et al.

    Eur J Pharm Sci. 2025 Aug 28:107249. doi: 10.1016/j.ejps.2025.107249. Online ahead of print.

    Published on August 30, 2025

    Sulfonation is one of drug metabolism reactions affecting homeostasis of estrogens. C-3 aryl substituted 7-hydroxycoumarins are fluorescent estrogen mimetics; i.e., the hydroxyl groups of both Read more

    PUBLICATION

    Cholesterol Ester Storage Disease in Two Field Spaniels With Lysosomal Acid Lipase Deficiency 

    Pernilla Syrjä et al.

    J Vet Intern Med. 2025 Sep-Oct;39(5):e70223. doi: 10.1111/jvim.70223.

    Published on August 27, 2025

    Cholesterol ester storage disease (CESD) is a rare genetic lysosomal storage disorder resulting from lower lysosomal acid lipase (LAL) activity. LAL is an essential enzyme Read more

    PUBLICATION

    The impact of conjugation strategies and linker density on the performance of the Spermine-AcDex nanoparticle-splenocyte conjugate 

    Yuchen Su et al.

    RSC Chem Biol. 2025 Jul 30. doi: 10.1039/d5cb00104h. Online ahead of print.

    Published on August 18, 2025

    A common approach in living medicine engineering is modifying cell surfaces with nanomedicines to form nanoparticle-cell conjugates. Despite various available strategies, limited research has examined Read more

    PUBLICATION

    A systematic approach to study the effects of acquisition parameters and biological factors on computerized mammography analysis using ex vivo human tissue: A protocol description 

    Nicole Hernández et al.

    PLoS One. 2025 Aug 18;20(8):e0321658. doi: 10.1371/journal.pone.0321658. eCollection 2025.

    Published on August 18, 2025

    BACKGROUND: Mammography is the most common imaging modality for the detection of breast cancer. Artificial intelligence algorithms for mammography analysis have shown promising performance for Read more

    PUBLICATION

    Detoxification of deoxynivalenol by pathogen-inducible tau-class glutathione transferases from wheat 

    Herbert Michlmayr et al.

    J Biol Chem. 2025 Aug 14:110600. doi: 10.1016/j.jbc.2025.110600. Online ahead of print.

    Published on August 16, 2025

    Deoxynivalenol (DON) is a toxicologically relevant trichothecene mycotoxin frequently found in cereal products. It is a virulence factor produced by the plant pathogen Fusarium graminearum Read more

    PUBLICATION

    Pharmacokinetics, Metabolism, and Toxicity of Anisomelic Acid and Ovatodiolide: Guiding Route of Administration in Preclinical Studies 

    Navid Delshad et al.

    Eur J Pharm Sci. 2025 Aug 12:107235. doi: 10.1016/j.ejps.2025.107235. Online ahead of print.

    Published on August 14, 2025

    Despite extensive progress in cancer therapeutic research, translating promising anticancer compounds into clinical treatments often fails due to suboptimal pharmacokinetic and safety profiles. These shortcomings Read more

    PUBLICATION

    Secreted Clever-1 modulates T cell responses and impacts cancer immunotherapy efficacy 

    Stuart Prince et al.

    Theranostics. 2025 Jun 23;15(15):7501-7527. doi: 10.7150/thno.110544. eCollection 2025.

    Published on August 4, 2025

    Rationale: Clever-1 is a multifunctional scavenger receptor that promotes immunosuppressive activity in macrophages, contributing to tumor immune evasion. Its high expression correlates with resistance to Read more

    PUBLICATION

    Phosphoproteomic analysis reveals the diversity of signaling behind ErbB-inhibitor-induced phenotypes 

    Katri Vaparanta et al.

    FEBS J. 2025 Jul 24. doi: 10.1111/febs.70197. Online ahead of print.

    Published on July 24, 2025

    The impact of kinase inhibitors on the phosphoproteome has been rarely investigated at a whole-organism level. Here, we performed a phosphoproteomic analysis in embryonic zebrafish Read more

    PUBLICATION

    Does cannabidiol reduce the adverse effects of cannabis in schizophrenia? A randomised, double-blind, cross-over trial 

    Edward Chesney et al.

    Neuropsychopharmacology. 2025 Jul 24. doi: 10.1038/s41386-025-02175-3. Online ahead of print.

    Published on July 23, 2025

    In patients with schizophrenia, cannabis use exacerbates symptoms and can lead to a relapse of psychosis. Some experimental studies in healthy volunteers suggest that pre-treatment Read more

    PUBLICATION

    Correction: The PP2A regulator IER5L supports prostate cancer progression 

    Jana R Crespo et al.

    Cell Death Dis. 2025 Jul 22;16(1):545. doi: 10.1038/s41419-025-07802-x.

    Published on July 22, 2025

    No abstract

    PUBLICATION

    LIMA1-alpha staining predicts curative intent surgery response in HPV negative head and neck cancer 

    Xi Qiao et al.

    EMBO Mol Med. 2025 Jul 17. doi: 10.1038/s44321-025-00266-8. Online ahead of print.

    Published on July 17, 2025

    In many solid cancer types, surgery alone could be a sufficient first therapy option for a significant number of cancer patients. However, there are currently Read more

    PUBLICATION

    EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration 

    Niklas Z Jäntti et al.

    Dev Cell. 2025 Jul 9:S1534-5807(25)00403-4. doi: 10.1016/j.devcel.2025.06.025. Online ahead of print.

    Published on July 16, 2025

    Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different cancers. The roles Read more