HDAC1 is involved in the destabilization of the HSF2 protein under non-stress and stress conditions 

Kevin Daupin et al.

Cell Stress Chaperones. 2025 May 1:100079. doi: 10.1016/j.cstres.2025.100079. Online ahead of print.

Published on May 3, 2025

Heat shock transcription factors 1 and 2 (HSF1 and HSF2) are the major regulators of the cellular response to stressors, notably to heat shock and Read more

Longitudinal pathway analysis using structural information with case studies in early type 1 diabetes 

Maria K Jaakkola et al.

Sci Rep. 2025 May 2;15(1):15393. doi: 10.1038/s41598-025-98492-0.

Published on May 2, 2025

Pathway analysis is a frequent step in studies involving gene or protein expression data, but most of the available pathway methods are designed for simple Read more

Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes 

Emil Hiitola et al.

Sci Adv. 2025 May 2;11(18):eadt9846. doi: 10.1126/sciadv.adt9846. Epub 2025 Apr 30.

Published on April 30, 2025

Clonal hematopoiesis (CH) becomes more prevalent with aging and may influence inflammatory diseases by altering immune function. While CH of indeterminate potential (CHIP) promotes inflammation Read more

Evaluation of Integrin Glycovariants as Biomarkers of Metastasis, Invasion, and Therapy Stratification in Head and Neck Squamous Cell Carcinoma 

Erica Routila et al.

Cancer Med. 2025 May;14(9):e70717. doi: 10.1002/cam4.70717.

Published on April 27, 2025

CONCLUSIONS: We demonstrate that while integrin glycovariants are abundant in HNSCC tumors and ITGB1-WFL was associated with invasiveness, integrin glycovariants do not directly correlate with Read more

Novel Genetic Risk Variants Associated with Oral Tongue Squamous Cell Carcinoma 

Rayan Nikkilä et al.

Head Neck Pathol. 2025 Apr 25;19(1):45. doi: 10.1007/s12105-025-01784-0.

Published on April 25, 2025

CONCLUSION: The GWAS detected two novel genetic associations with OTSCC. Further research is needed to identify the genes at these loci that contribute to the Read more

Histological tumor necrosis predicts decreased survival after neoadjuvant chemotherapy in head and neck squamous cell carcinoma 

A R Koskenniemi et al.

Oral Oncol. 2025 Jun;165:107287. doi: 10.1016/j.oraloncology.2025.107287. Epub 2025 Apr 16.

Published on April 17, 2025

CONCLUSIONS: Detection of tumor necrosis and AI-driven deep learning effectively predict neoadjuvant RT/CRT responses in HNSCC.

Heat shock factor 2 regulates oncogenic gamma-herpesvirus gene expression by remodeling the chromatin at the ORF50 and BZLF1 promoter 

Lorenza Cutrone et al.

PLoS Pathog. 2025 Apr 17;21(4):e1013108. doi: 10.1371/journal.ppat.1013108. eCollection 2025 Apr.

Published on April 17, 2025

The Human gamma-herpesviruses Kaposi's sarcoma herpesvirus (KSHV) and Epstein-Barr virus (EBV) are causally associated to a wide range of cancers. While the default infection program Read more

Surface Modification of Mesoporous Silica Nanoparticles as a Means to Introduce Inherent Cancer-Targeting Ability in a 3D Tumor Microenvironment 

Neeraj Prabhakar et al.

Small Sci. 2024 Jul 8;4(9):2400084. doi: 10.1002/smsc.202400084. eCollection 2024 Sep.

Published on April 11, 2025

Mesoporous silica nanoparticles (MSNs) have emerged as promising drug carriers that can facilitate targeted anticancer drug delivery, but efficiency studies relying on active targeting mechanisms Read more

mTORC1 shutdown unleashes TFEB to drive triple-negative breast cancer invasion 

Michalis Gounis et al.

Dev Cell. 2025 Apr 7;60(7):979-981. doi: 10.1016/j.devcel.2025.03.006.

Published on April 8, 2025

The PI3K/AKT/mTOR pathway is considered a key therapeutic target in triple-negative breast cancer (TNBC). In this issue of Developmental Cell, Remy et al. challenge this Read more

Practical considerations for data exploration in quantitative cell biology 

Joanna W Pylvänäinen et al.

J Cell Sci. 2025 Apr 1;138(7):jcs263801. doi: 10.1242/jcs.263801. Epub 2025 Apr 7.

Published on April 7, 2025

Data exploration is an essential step in quantitative cell biology, bridging raw data and scientific insights. Unlike polished, published figures, effective data exploration requires a Read more

Regulating macrophage glucose metabolism homeostasis via mitochondrial rheostats by short fiber-microsphere scaffolds for bone repair 

Pengzhen Zhuang et al.

Bioact Mater. 2025 Mar 15;49:399-417. doi: 10.1016/j.bioactmat.2025.03.008. eCollection 2025 Jul.

Published on March 27, 2025

The alterations in glucose metabolism flux induced by mitochondrial function changes are crucial for regulating bone immune homeostasis. The restoration of mitochondrial homeostasis, serving as Read more

Time, the final frontier 

Gautier Follain et al.

Mol Oncol. 2025 Mar 24. doi: 10.1002/1878-0261.70025. Online ahead of print.

Published on March 24, 2025

Cancer's notorious heterogeneity poses significant challenges, as each tumor comprises a unique ecosystem. While single-cell and spatial transcriptomics advancements have transformed our understanding of spatial Read more