Publications

    Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes 

    Emil Hiitola et al.

    Sci Adv. 2025 May 2;11(18):eadt9846. doi: 10.1126/sciadv.adt9846. Epub 2025 Apr 30.

    Published on April 30, 2025

    Clonal hematopoiesis (CH) becomes more prevalent with aging and may influence inflammatory diseases by altering immune function. While CH of indeterminate potential (CHIP) promotes inflammation Read more

    Evaluation of Integrin Glycovariants as Biomarkers of Metastasis, Invasion, and Therapy Stratification in Head and Neck Squamous Cell Carcinoma 

    Erica Routila et al.

    Cancer Med. 2025 May;14(9):e70717. doi: 10.1002/cam4.70717.

    Published on April 27, 2025

    CONCLUSIONS: We demonstrate that while integrin glycovariants are abundant in HNSCC tumors and ITGB1-WFL was associated with invasiveness, integrin glycovariants do not directly correlate with Read more

    Novel Genetic Risk Variants Associated with Oral Tongue Squamous Cell Carcinoma 

    Rayan Nikkilä et al.

    Head Neck Pathol. 2025 Apr 25;19(1):45. doi: 10.1007/s12105-025-01784-0.

    Published on April 25, 2025

    CONCLUSION: The GWAS detected two novel genetic associations with OTSCC. Further research is needed to identify the genes at these loci that contribute to the Read more

    Histological tumor necrosis predicts decreased survival after neoadjuvant chemotherapy in head and neck squamous cell carcinoma 

    A R Koskenniemi et al.

    Oral Oncol. 2025 Jun;165:107287. doi: 10.1016/j.oraloncology.2025.107287. Epub 2025 Apr 16.

    Published on April 17, 2025

    CONCLUSIONS: Detection of tumor necrosis and AI-driven deep learning effectively predict neoadjuvant RT/CRT responses in HNSCC.

    Heat shock factor 2 regulates oncogenic gamma-herpesvirus gene expression by remodeling the chromatin at the ORF50 and BZLF1 promoter 

    Lorenza Cutrone et al.

    PLoS Pathog. 2025 Apr 17;21(4):e1013108. doi: 10.1371/journal.ppat.1013108. eCollection 2025 Apr.

    Published on April 17, 2025

    The Human gamma-herpesviruses Kaposi's sarcoma herpesvirus (KSHV) and Epstein-Barr virus (EBV) are causally associated to a wide range of cancers. While the default infection program Read more

    Surface Modification of Mesoporous Silica Nanoparticles as a Means to Introduce Inherent Cancer-Targeting Ability in a 3D Tumor Microenvironment 

    Neeraj Prabhakar et al.

    Small Sci. 2024 Jul 8;4(9):2400084. doi: 10.1002/smsc.202400084. eCollection 2024 Sep.

    Published on April 11, 2025

    Mesoporous silica nanoparticles (MSNs) have emerged as promising drug carriers that can facilitate targeted anticancer drug delivery, but efficiency studies relying on active targeting mechanisms Read more

    mTORC1 shutdown unleashes TFEB to drive triple-negative breast cancer invasion 

    Michalis Gounis et al.

    Dev Cell. 2025 Apr 7;60(7):979-981. doi: 10.1016/j.devcel.2025.03.006.

    Published on April 8, 2025

    The PI3K/AKT/mTOR pathway is considered a key therapeutic target in triple-negative breast cancer (TNBC). In this issue of Developmental Cell, Remy et al. challenge this Read more

    Practical considerations for data exploration in quantitative cell biology 

    Joanna W Pylvänäinen et al.

    J Cell Sci. 2025 Apr 1;138(7):jcs263801. doi: 10.1242/jcs.263801. Epub 2025 Apr 7.

    Published on April 7, 2025

    Data exploration is an essential step in quantitative cell biology, bridging raw data and scientific insights. Unlike polished, published figures, effective data exploration requires a Read more

    Regulating macrophage glucose metabolism homeostasis via mitochondrial rheostats by short fiber-microsphere scaffolds for bone repair 

    Pengzhen Zhuang et al.

    Bioact Mater. 2025 Mar 15;49:399-417. doi: 10.1016/j.bioactmat.2025.03.008. eCollection 2025 Jul.

    Published on March 27, 2025

    The alterations in glucose metabolism flux induced by mitochondrial function changes are crucial for regulating bone immune homeostasis. The restoration of mitochondrial homeostasis, serving as Read more

    Time, the final frontier 

    Gautier Follain et al.

    Mol Oncol. 2025 Mar 24. doi: 10.1002/1878-0261.70025. Online ahead of print.

    Published on March 24, 2025

    Cancer's notorious heterogeneity poses significant challenges, as each tumor comprises a unique ecosystem. While single-cell and spatial transcriptomics advancements have transformed our understanding of spatial Read more

    Increased primary breast tumor expression of CD73 is associated with development of bone metastases and is a potential biomarker for adjuvant bisphosphonate use 

    Nataliia Petruk et al.

    Sci Rep. 2025 Mar 19;15(1):9449. doi: 10.1038/s41598-025-92841-9.

    Published on March 20, 2025

    CONCLUSIONS: High CD73 expression is associated with development of bone metastases. Zoledronate counteracts this effect. These results suggest that CD73 expression might serve as a Read more

    Practical recommendations for developing software for life science applications 

    Joanna W Pylvänäinen et al.

    J Cell Sci. 2025 Mar 1;138(5):jcs263711. doi: 10.1242/jcs.263711. Epub 2025 Mar 17.

    Published on March 17, 2025

    Developing user-friendly image analysis software is essential for advancing biological and life science research. However, the interdisciplinary gap between software developers and life scientists presents Read more