Publications

    PUBLICATION

    In situ construction of ossification micro-units for critical bone regeneration via sustained lifting of epigenetic suppression 

    Wu Yang et al.

    J Control Release. 2025 Jun 23:113978. doi: 10.1016/j.jconrel.2025.113978. Online ahead of print.

    Published on June 25, 2025

    Critical-sized bone defects present significant clinical challenges due to insufficient stem cell recruitment, epigenetic suppression of osteogenesis, and inadequate mineralization. Among the epigenetic suppression mechanisms, Read more

    PUBLICATION

    Cytoskeletal crosstalk in macrophages: Vimentin drives ECM remodeling in tumor invasion and tissue plasticity 

    John E Eriksson et al.

    Dev Cell. 2025 Jun 23;60(12):1655-1657. doi: 10.1016/j.devcel.2025.05.015.

    Published on June 24, 2025

    In this issue of Developmental Cell, Huang et al. assess the role of vimentin intermediate filaments during extracellular matrix (ECM) degradation by macrophages. Vimentin stabilizes Read more

    PUBLICATION

    Integrin β1 activity controls colony morphology during human pluripotent stem cell state transitions 

    Maria E Taskinen et al.

    Stem Cell Reports. 2025 Jun 17:102538. doi: 10.1016/j.stemcr.2025.102538. Online ahead of print.

    Published on June 20, 2025

    Integrin β1-mediated adhesion is dispensable in early mouse embryogenesis (pre-implantation) but indispensable post-implantation, suggesting distinct roles for β1-integrin-mediated adhesions in the naive (pre-implantation) versus primed Read more

    PUBLICATION

    The Next Frontier: Unveiling Novel Approaches for Combating Multidrug-Resistant Bacteria 

    Praveen Mallari et al.

    Pharm Res. 2025 Jun 16. doi: 10.1007/s11095-025-03871-x. Online ahead of print.

    Published on June 16, 2025

    CONCLUSION: Despite the substantial obstacles to getting bench findings to the patient, numerous scientists are still working towards this goal. Both the application of antibiotic Read more

    PUBLICATION

    A metabolite-based resistance mechanism against malaria 

    Ana Figueiredo et al.

    Science. 2025 Jun 12;388(6752):eadq6741. doi: 10.1126/science.adq6741. Epub 2025 Jun 12.

    Published on June 12, 2025

    Jaundice is a common presentation of Plasmodium falciparum malaria, which arises from the accumulation of circulating bilirubin. It is not understood whether it represents an Read more

    PUBLICATION

    NRF2-mediated persistent adaptation of oesophageal adenocarcinoma cells to HER2 inhibition 

    Wei Zhang et al.

    Oncogene. 2025 Jun 5. doi: 10.1038/s41388-025-03459-0. Online ahead of print.

    Published on June 5, 2025

    The human epidermal growth factor receptor 2 (HER2, also known as ERBB2) is a commonly over-expressed oncoprotein in oesophageal adenocarcinoma (OAC). Nonetheless, HER2-blocking agents have Read more

    PUBLICATION

    Biochemical and structural characterization of chlorite dismutase enzyme from Pseudomonas aeruginosa 

    Dimitrios V Nokas et al.

    FEBS J. 2025 Jun 3. doi: 10.1111/febs.70151. Online ahead of print.

    Published on June 3, 2025

    Industrialization and urbanization have caused serious contamination of water bodies, and the removal of chemical contaminants has become a major challenge. Chlorite is a harmful Read more

    PUBLICATION

    A guide to heat shock factors as multifunctional transcriptional regulators 

    Hendrik S E Hästbacka et al.

    FEBS J. 2025 Jun 2. doi: 10.1111/febs.70139. Online ahead of print.

    Published on June 2, 2025

    The heat shock factors (HSFs) form a family of transcription factors, which are evolutionarily conserved in eukaryotes. They are best known as transcriptional regulators of Read more

    PUBLICATION

    Proliferation of Human Cervical Cancer Cells Responds to Surface Properties of Bicomponent Polymer Coatings 

    Emil Rosqvist et al.

    Nanomaterials (Basel). 2025 May 9;15(10):716. doi: 10.3390/nano15100716.

    Published on May 27, 2025

    The proliferation of human cervical cancer (Hela) cells was investigated on a series of nanostructured polymer latex surfaces. The physico-chemical properties of the surfaces, composed Read more

    PUBLICATION

    Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells 

    James R W Conway et al.

    Nat Cell Biol. 2025 May 26. doi: 10.1038/s41556-025-01663-4. Online ahead of print.

    Published on May 26, 2025

    Integrins provide an essential bridge between cancer cells and the extracellular matrix, playing a central role in every stage of disease progression. Despite the recognized Read more

    PUBLICATION

    Mass spectrometric insights into the protein composition of human cutaneous neurofibromas: comparison of neurofibromas with the overlying skin 

    Roope A Kallionpää et al.

    Br J Cancer. 2025 May 20. doi: 10.1038/s41416-025-03055-9. Online ahead of print.

    Published on May 20, 2025

    CONCLUSION: The cNFs are relatively quiescent, consistent with their benign nature and limited growth potential. The development of pharmacological therapy for cNFs requires overcoming the Read more

    PUBLICATION

    High-resolution live imaging of tardigrade response to anoxia 

    Anna-Mari Haapanen-Saaristo et al.

    Micron. 2025 May 9;196-197:103847. doi: 10.1016/j.micron.2025.103847. Online ahead of print.

    Published on May 14, 2025

    Tardigrades are well-known for their ability to tolerate extreme environmental conditions such as heat, drought and lack of oxygen by undergoing cryptobiosis. The molecular responses Read more