Biochemical and structural characterization of chlorite dismutase enzyme from Pseudomonas aeruginosa 

Dimitrios V Nokas et al.

FEBS J. 2025 Jun 3. doi: 10.1111/febs.70151. Online ahead of print.

Published on June 3, 2025

Industrialization and urbanization have caused serious contamination of water bodies, and the removal of chemical contaminants has become a major challenge. Chlorite is a harmful Read more

A guide to heat shock factors as multifunctional transcriptional regulators 

Hendrik S E Hästbacka et al.

FEBS J. 2025 Jun 2. doi: 10.1111/febs.70139. Online ahead of print.

Published on June 2, 2025

The heat shock factors (HSFs) form a family of transcription factors, which are evolutionarily conserved in eukaryotes. They are best known as transcriptional regulators of Read more

Proliferation of Human Cervical Cancer Cells Responds to Surface Properties of Bicomponent Polymer Coatings 

Emil Rosqvist et al.

Nanomaterials (Basel). 2025 May 9;15(10):716. doi: 10.3390/nano15100716.

Published on May 27, 2025

The proliferation of human cervical cancer (Hela) cells was investigated on a series of nanostructured polymer latex surfaces. The physico-chemical properties of the surfaces, composed Read more

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells 

James R W Conway et al.

Nat Cell Biol. 2025 May 26. doi: 10.1038/s41556-025-01663-4. Online ahead of print.

Published on May 26, 2025

Integrins provide an essential bridge between cancer cells and the extracellular matrix, playing a central role in every stage of disease progression. Despite the recognized Read more

Mass spectrometric insights into the protein composition of human cutaneous neurofibromas: comparison of neurofibromas with the overlying skin 

Roope A Kallionpää et al.

Br J Cancer. 2025 May 20. doi: 10.1038/s41416-025-03055-9. Online ahead of print.

Published on May 20, 2025

CONCLUSION: The cNFs are relatively quiescent, consistent with their benign nature and limited growth potential. The development of pharmacological therapy for cNFs requires overcoming the Read more

High-resolution live imaging of tardigrade response to anoxia 

Anna-Mari Haapanen-Saaristo et al.

Micron. 2025 May 9;196-197:103847. doi: 10.1016/j.micron.2025.103847. Online ahead of print.

Published on May 14, 2025

Tardigrades are well-known for their ability to tolerate extreme environmental conditions such as heat, drought and lack of oxygen by undergoing cryptobiosis. The molecular responses Read more

CellRomeR: an R package for clustering cell migration phenotypes from microscopy data 

Iivari Kleino et al.

Bioinform Adv. 2025 Apr 4;5(1):vbaf069. doi: 10.1093/bioadv/vbaf069. eCollection 2025.

Published on May 7, 2025

MOTIVATION: The analysis of cell migration using time-lapse microscopy typically focuses on track characteristics for classification and statistical evaluation of migration behaviour. However, considerable heterogeneity Read more

The ERBB2 c.1795C>T, p.Arg599Cys variant is associated with left ventricular outflow tract obstruction defects in humans 

Minna Ampuja et al.

HGG Adv. 2025 May 5;6(3):100446. doi: 10.1016/j.xhgg.2025.100446. Online ahead of print.

Published on May 7, 2025

Non-syndromic congenital heart defects (CHDs) are occasionally familial and left ventricular outflow tract obstruction (LVOTO) defects are among the subtypes with the highest hereditability. The Read more

HDAC1 is involved in the destabilization of the HSF2 protein under non-stress and stress conditions 

Kevin Daupin et al.

Cell Stress Chaperones. 2025 May 1:100079. doi: 10.1016/j.cstres.2025.100079. Online ahead of print.

Published on May 3, 2025

Heat shock transcription factors 1 and 2 (HSF1 and HSF2) are the major regulators of the cellular response to stressors, notably to heat shock and Read more

Longitudinal pathway analysis using structural information with case studies in early type 1 diabetes 

Maria K Jaakkola et al.

Sci Rep. 2025 May 2;15(1):15393. doi: 10.1038/s41598-025-98492-0.

Published on May 2, 2025

Pathway analysis is a frequent step in studies involving gene or protein expression data, but most of the available pathway methods are designed for simple Read more

Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes 

Emil Hiitola et al.

Sci Adv. 2025 May 2;11(18):eadt9846. doi: 10.1126/sciadv.adt9846. Epub 2025 Apr 30.

Published on April 30, 2025

Clonal hematopoiesis (CH) becomes more prevalent with aging and may influence inflammatory diseases by altering immune function. While CH of indeterminate potential (CHIP) promotes inflammation Read more

Evaluation of Integrin Glycovariants as Biomarkers of Metastasis, Invasion, and Therapy Stratification in Head and Neck Squamous Cell Carcinoma 

Erica Routila et al.

Cancer Med. 2025 May;14(9):e70717. doi: 10.1002/cam4.70717.

Published on April 27, 2025

CONCLUSIONS: We demonstrate that while integrin glycovariants are abundant in HNSCC tumors and ITGB1-WFL was associated with invasiveness, integrin glycovariants do not directly correlate with Read more