No abstract…
Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe
Sprouting angiogenesis and blood vessel stabilization require precise coordination between endothelial cells (ECs) and pericytes. Bone Morphogenic Protein 9 (Bmp9), whose signaling through activin receptor-like kinase 1 (Alk1) is dysregulated…
Complete Data Analysis Workflow for Quantitative DIA Mass Spectrometry Using Nextflow
Data-independent acquisition (DIA) mass spectrometry is a technique used in proteomics to identify and quantify proteins in complex biological samples. While this comprehensive approach yields more complete and reproducible protein…
High-sensitivity, protein-independent detection of dsDNA sequences
Current methodologies for detecting the sequence of double-stranded DNA (dsDNA) require amplifying and denaturing the target into single-stranded DNA (ssDNA) to enable sequence detection through Watson-Crick base pairing. However, these…
Prenatal exposure to persistent organic pollutants modulates the metabolism and gut microbiota of the offspring
Emerging evidence suggests that environmental contaminants can influence both human metabolism and gut microbiota composition. However, the specific effects of prenatal exposure to persistent organic pollutants (POPs) on host-microbiome metabolic…
Preventing Proteomics Data Tombs Through Collective Responsibility and Community Engagement
Public proteomics repositories now host vast amounts of mass spectrometry data, yet much of it remains difficult to reuse, risking “data tombs” that are open access but not practically re-analyzable.
Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells
Metastases arise from a multistep process during which tumour cells face several microenvironmental mechanical challenges, which influence metastatic success. However, how circulating tumour cells (CTCs) adapt their mechanics to such…
Progressive fibrosis in human MASLD is associated with spatially linked transcriptomic signatures of metabolic reprogramming and senescence
CONCLUSIONS: Taken together, our valuable discovery dataset highlights the complex crosstalk between metabolic perturbations and inflammation underpinning fibrosis progression in MASLD.