The appearance of diabetes-associated autoantibodies is the first detectable sign of the disease process leading to type 1 diabetes (T1D). Evidence suggests that T1D is a heterogenous disease, where the…
Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties
Increased extracellular matrix deposition and stiffness promotes solid tumour progression. Yet, the precise mechanotransduction pathways, especially in less-studied mechanically responsive cancers, remain poorly understood. Here we address this gap using…
Spatial single-cell analysis reveals tumor microenvironment signatures predictive of oral cavity cancer outcome
Up to 20% of patients with early-stage oral squamous cell carcinoma (OSCC) develop postoperative relapse, but no parameters currently enable the identification of individuals with poor prognosis. Here, we report…
Complete Data Analysis Workflow for Quantitative DIA Mass Spectrometry Using Nextflow
Data-independent acquisition (DIA) mass spectrometry is a technique used in proteomics to identify and quantify proteins in complex biological samples. While this comprehensive approach yields more complete and reproducible protein…
Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe
Sprouting angiogenesis and blood vessel stabilization require precise coordination between endothelial cells (ECs) and pericytes. Bone Morphogenic Protein 9 (Bmp9), whose signaling through activin receptor-like kinase 1 (Alk1) is dysregulated…
High-sensitivity, protein-independent detection of dsDNA sequences
Current methodologies for detecting the sequence of double-stranded DNA (dsDNA) require amplifying and denaturing the target into single-stranded DNA (ssDNA) to enable sequence detection through Watson-Crick base pairing. However, these…
Prenatal exposure to persistent organic pollutants modulates the metabolism and gut microbiota of the offspring
Emerging evidence suggests that environmental contaminants can influence both human metabolism and gut microbiota composition. However, the specific effects of prenatal exposure to persistent organic pollutants (POPs) on host-microbiome metabolic…