Early-life gut microbiome-metabolome crosstalk plays a crucial role in maintaining host physiology. The microbially produced metabolites often convey effects on host health and physiology. This study investigates the gut metabolites,…
Complement components C1r and C1s promote oral squamous cell carcinoma cell proliferation
CONCLUSIONS: The complement system may be a common molecular mechanism for OSCC tumorigenesis, which arises from different origins: odontogenic and mucosal epithelium. Elevated C1r/C1s expression contributes to OSCC cell proliferation.
Hepatic zonation determines tumorigenic potential of mutant β-catenin
Oncogenic mutations in phenotypically normal tissue are common across adult organs^(1,2). This suggests that multiple events need to converge to drive tumorigenesis and that many processes such as tissue differentiation…
Breast cancer remodels lymphatics in sentinel lymph nodes
Cancer metastasis to sentinel lymph nodes (LNs) is often the first marker of potential disease progression. Although it is recognized that tumor-induced lymphangiogenesis facilitates metastasis into LNs in murine models,…
LINC01871 is exclusively expressed in T and NK cells and is highly induced upon CD4+ T cell activation
Long intergenic noncoding RNAs (lincRNAs) regulate biological processes in health and disease. Recent findings highlight the importance of lincRNAs in regulating T cell development and function. Here, we identified a…
Coralysis enables sensitive identification of imbalanced cell types and states in single-cell data via multi-level integration
Complex single-cell analyses now routinely integrate multiple datasets, followed by cell-type annotation and differential expression analysis. Current state-of-the-art integration methods often struggle with imbalanced cell types across datasets particularly when…
Single-cell to pre-clinical evaluation of Trem2, Folr2, and Slc7a7 as macrophage-associated biomarkers for atherosclerosis
CONCLUSIONS: Our findings provide novel insights into macrophage-specific gene programs during atherosclerosis progression and identify a set of promising biomarkers that can serve as a resource for future studies. These…
Drug target proteome profiling identifies HES1-driven mitotic catastrophe in ovarian serous carcinoma
Ovarian high-grade serous cancer (HGSC) is the most aggressive ovarian cancer subtype with limited treatment options. We identify the PDPK1 inhibitor BX-912 as a promising candidate, showing strong single-agent activity…
Nextpie: a web-based reporting tool and database for reproducible nextflow pipelines
MOTIVATION: High-throughput genomic data analysis consists of the inexorably intertwined inputs and outputs of a vast array of bioinformatic analysis tools. To guarantee streamlined and reproducible analyses, the often complex…
Reinstating Niche Failure in Diabetic Cranial Defects via Chronotaxic Signal-Amplifying Fluidic Biomimetic Hydrogel
Cranial stem cell niches (SCNs) are intrinsically scarce and hypoactive, and, exacerbated by chronic inflammation in diabetes, lead to niche failure and regenerative deficit after injury. Herein, an in situ…