Frontiers of Science: The molecular chaperone Hsp90: probing its functions with drugs and gene deletion
Prof. Didier Picard, University of Geneva, Switzerland
online event at 12:00
The molecular chaperone Hsp90: probing its functions with drugs and gene deletions
host: Outi Salo-Ahen (firstname.lastname@example.org)
Register latest April 7th 12:00
Students and early-career postdocs are welcome to share a virtual cup of coffee and discuss with Prof. Picard after the seminar. This is a great possibility to learn hosting skills in friendly environment and create connections for future. Every student are welcome to join, in spite of which research group they belong to.
If you got interested, after registering to the event please send an email to email@example.com
Didier Picard is a professor and a research group leader in the department of cell biology in the University of Geneva, Switzerland. His research interests lies in signal integration at the cellular level and its implications in breast cancer, and particularly in understanding the molecular mechanisms of signal transduction by ER and its crosstalk with other intra- and extracellular signals. His group studies also the Hsp90 molecular chaperone machine where they are particularly interested in determining the in vivo functions of the Hsp90 molecular chaperone complex both in mammalian cells and in the mouse, using genetic, biochemical, proteomic and pharmacological tools.
A Joshi, L Dai, Y Liu, J Lee, NM Ghahhari… D Picard (2020) The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis. BMC Biol. 18, 10
K Bhattacharya, L Weidenauer, TM Luengo… D Picard (2020) The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation. Nature Communications 11:5975
Segala G, Bennesch MA, Ghahhari NM, Pandey DP, Echeverria PC, Karch F, Maeda RK, Picard D (2019) Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling. Nature Communications 10:1833
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