Publications

    PUBLICATION

    The role and regulation of integrins in cell migration and invasion 

    Megan R Chastney et al.

    Nat Rev Mol Cell Biol. 2025 Feb;26(2):147-167. doi: 10.1038/s41580-024-00777-1. Epub 2024 Sep 30.

    Published on September 30, 2024

    Integrin receptors are the main molecular link between cells and the extracellular matrix (ECM) as well as mediating cell-cell interactions. Integrin-ECM binding triggers the formation Read more

    PUBLICATION

    Profiling steroid hormone landscape of bladder cancer reveals depletion of intratumoural androgens to castration levels: a cross-sectional study 

    Kimmo Kettunen et al.

    EBioMedicine. 2024 Oct;108:105359. doi: 10.1016/j.ebiom.2024.105359. Epub 2024 Sep 28.

    Published on September 29, 2024

    BACKGROUND: Bladder cancer is a highly over-represented disease in males. The involvement of sex steroids in bladder carcinogenesis and the utilisation of steroid hormone action Read more

    PUBLICATION

    Empagliflozin attenuates hypoxia-induced heart failure of zebrafish embryos via influencing MMP13 expression 

    R Huttunen et al.

    Biomed Pharmacother. 2024 Nov;180:117453. doi: 10.1016/j.biopha.2024.117453. Epub 2024 Sep 26.

    Published on September 27, 2024

    CONCLUSIONS: Our study shows that empagliflozin´s favorable effect on attenuating HF is mediated via MMP13. MMP13 provides a novel option when developing new therapeutics for Read more

    PUBLICATION

    IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis 

    Peng Zhang et al.

    Cell Metab. 2024 Oct 1;36(10):2341-2354.e6. doi: 10.1016/j.cmet.2024.08.012. Epub 2024 Sep 23.

    Published on September 24, 2024

    The exponential rise in metabolic dysfunction-associated steatotic liver disease (MASLD) parallels the ever-increasing consumption of energy-dense diets, underscoring the need for effective MASLD-resolving drugs. MASLD Read more

    PUBLICATION

    Atomistic simulations reveal impacts of missense mutations on the structure and function of SynGAP1 

    Aliaa E Ali et al.

    Brief Bioinform. 2024 Sep 23;25(6):bbae458. doi: 10.1093/bib/bbae458.

    Published on September 23, 2024

    De novo mutations in the synaptic GTPase activating protein (SynGAP) are associated with neurological disorders like intellectual disability, epilepsy, and autism. SynGAP is also implicated Read more

    PUBLICATION

    Single-cell transcriptome analysis of the early immune response in the lymph nodes of Borrelia burgdorferi-infected mice 

    Varpu Rinne et al.

    Microbes Infect. 2025 Feb;27(2):105424. doi: 10.1016/j.micinf.2024.105424. Epub 2024 Sep 19.

    Published on September 21, 2024

    Lyme borreliosis is a disease caused by Borrelia burgdorferi sensu lato bacteria. Borrelia burgdorferi is known to induce prolonged extrafollicular immune responses and abnormal germinal Read more

    PUBLICATION

    Proteomic profiling identifies a direct interaction between heat shock transcription factor 2 and the focal adhesion adapter talin-1 

    Alejandro J Da Silva et al.

    FEBS J. 2024 Nov;291(21):4830-4848. doi: 10.1111/febs.17271. Epub 2024 Sep 16.

    Published on September 17, 2024

    Heat shock factor 2 (HSF2) is a versatile transcription factor that regulates gene expression under stress conditions, during development, and in disease. Despite recent advances Read more

    PUBLICATION

    Heat stress sensitizes zebrafish embryos to neurological and cardiac toxicity 

    Anna-Mari Haapanen-Saaristo et al.

    Biochem Biophys Res Commun. 2024 Nov 12;733:150682. doi: 10.1016/j.bbrc.2024.150682. Epub 2024 Sep 10.

    Published on September 14, 2024

    Global warming increases the risk of dangerous heat waves, which may have deleterious effects on humans and wildlife. Here, we have utilized zebrafish embryos as Read more

    PUBLICATION

    Phenotypic profiling of human induced regulatory T cells at early differentiation: insights into distinct immunosuppressive potential 

    Roosa Kattelus et al.

    Cell Mol Life Sci. 2024 Sep 12;81(1):399. doi: 10.1007/s00018-024-05429-3.

    Published on September 12, 2024

    Regulatory T cells (Tregs) play a key role in suppressing systemic effector immune responses, thereby preventing autoimmune diseases but also potentially contributing to tumor progression. Read more

    PUBLICATION

    Comparative proteomics analysis of the mouse mini-gut organoid: insights into markers of gluten challenge from celiac disease intestinal biopsies 

    Robert Moulder et al.

    Front Mol Biosci. 2024 Aug 28;11:1446822. doi: 10.3389/fmolb.2024.1446822. eCollection 2024.

    Published on September 12, 2024

    INTRODUCTION: Organoid models enable three-dimensional representation of cellular systems, providing flexible and accessible research tools, and can highlight key biomolecules. Such models of the intestinal Read more

    PUBLICATION

    SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers 

    Johanna Lilja et al.

    Nat Commun. 2024 Sep 12;15(1):8002. doi: 10.1038/s41467-024-52326-1.

    Published on September 12, 2024

    The KRAS oncogene drives many common and highly fatal malignancies. These include pancreatic, lung, and colorectal cancer, where various activating KRAS mutations have made the Read more

    PUBLICATION

    Hypoxia and Foxn1 alter the proteomic signature of dermal fibroblasts to redirect scarless wound healing to scar-forming skin wound healing in Foxn1-/- mice 

    Barbara Gawronska-Kozak et al.

    BMC Biol. 2024 Sep 11;22(1):193. doi: 10.1186/s12915-024-01990-2.

    Published on September 10, 2024

    CONCLUSIONS: The present data highlight the effect of hypoxia and Foxn1 on the protein profile and functionality of regenerative Foxn1^(-/-) DFs and demonstrate that the Read more