Publications

    Multi-omics analysis reveals drivers of loss of β-cell function after newly diagnosed autoimmune type 1 diabetes: An INNODIA multicenter study 

    Jose Juan Almagro Armenteros et al.

    Diabetes Metab Res Rev. 2024 Jul;40(5):e3833. doi: 10.1002/dmrr.3833.

    Published on July 4, 2024

    CONCLUSIONS: Features that differ between individuals with slow and rapid decline in β-cell mass could be valuable in staging and prediction of the rate of Read more

    Cancer cell invasion alters the protein profile of extracellular vesicles 

    Jens C Luoto et al.

    J Extracell Biol. 2023 Nov 27;2(12):e124. doi: 10.1002/jex2.124. eCollection 2023 Dec.

    Published on June 28, 2024

    Extracellular vesicles (EVs) are important mediators of intercellular communication involved in local and long-range signalling of cancer metastasis. The onset of invasion is the key Read more

    SNM1A is crucial for efficient repair of complex DNA breaks in human cells 

    Lonnie P Swift et al.

    Nat Commun. 2024 Jun 25;15(1):5392. doi: 10.1038/s41467-024-49583-5.

    Published on June 25, 2024

    DNA double-strand breaks (DSBs), such as those produced by radiation and radiomimetics, are amongst the most toxic forms of cellular damage, in part because they Read more

    Wnt/β-catenin-YAP axis in the pathogenesis of primary intraosseous carcinoma NOS, deriving from odontogenic keratocyst 

    Yusuke Nakako et al.

    Pathol Res Pract. 2024 Aug;260:155420. doi: 10.1016/j.prp.2024.155420. Epub 2024 Jun 20.

    Published on June 22, 2024

    Odontogenic tumors (OGTs), which originate from cells of odontogenic apparatus and their remnants, are rare entities. Primary intraosseous carcinoma NOS (PIOC), is one of the Read more

    DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer 

    Majid Momeny et al.

    EMBO Mol Med. 2024 Jul;16(7):1603-1629. doi: 10.1038/s44321-024-00088-0. Epub 2024 Jun 17.

    Published on June 17, 2024

    Despite clinical benefits of tyrosine kinase inhibitors (TKIs) in cancer, most tumors can reactivate proliferation under TKI therapy. Here we present transcriptional profiling of HER2+ Read more

    Serum proteomics of mother-infant dyads carrying HLA-conferred type 1 diabetes risk 

    Santosh D Bhosale et al.

    iScience. 2024 May 22;27(6):110048. doi: 10.1016/j.isci.2024.110048. eCollection 2024 Jun 21.

    Published on June 17, 2024

    In-utero and dietary factors make important contributions toward health and development in early childhood. In this respect, serum proteomics of maturing infants can provide insights Read more

    Improved breast milk proteome coverage by DIA based LC-MS/MS method 

    Jenni Viitaharju et al.

    Proteomics. 2024 Jul;24(14):e2300340. doi: 10.1002/pmic.202300340. Epub 2024 Jun 14.

    Published on June 14, 2024

    The breast milk composition includes a multitude of bioactive factors such as viable cells, lipids and proteins. Measuring the levels of specific proteins in breast Read more

    Indignity of Nazi data: reflections on the utilization of illicit research 

    Iman Farahani et al.

    Med Health Care Philos. 2024 Sep;27(3):381-387. doi: 10.1007/s11019-024-10212-z. Epub 2024 Jun 6.

    Published on June 6, 2024

    Human rights may feel self-apparent to us, but less than 80 years ago, one of the most advanced countries at the time acted based on Read more

    Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease 

    Samira Salihovic et al.

    Nat Commun. 2024 Jun 3;15(1):4567. doi: 10.1038/s41467-024-48763-7.

    Published on June 3, 2024

    Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples Read more

    Trans-activating mutations of the pseudokinase ERBB3 

    Marika K A Koivu et al.

    Oncogene. 2024 Jul;43(29):2253-2265. doi: 10.1038/s41388-024-03070-9. Epub 2024 May 28.

    Published on May 28, 2024

    Genetic changes in the ERBB family of receptor tyrosine kinases serve as oncogenic driver events and predictive biomarkers for ERBB inhibitor drugs. ERBB3 is a Read more

    Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive function of human CD4+ regulatory T cells by regulating IL2RA 

    Syed Bilal Ahmad Andrabi et al.

    Proc Natl Acad Sci U S A. 2024 Jun 4;121(23):e2315363121. doi: 10.1073/pnas.2315363121. Epub 2024 May 28.

    Published on May 28, 2024

    Regulatory T cells (Tregs) are central in controlling immune responses, and dysregulation of their function can lead to autoimmune disorders or cancer. Despite extensive studies Read more

    A proximal enhancer regulates RORA expression during early human Th17 cell differentiation 

    Ubaid Ullah Kalim et al.

    Clin Immunol. 2024 Jul;264:110261. doi: 10.1016/j.clim.2024.110261. Epub 2024 May 22.

    Published on May 24, 2024

    Gene regulatory elements, such as enhancers, greatly influence cell identity by tuning the transcriptional activity of specific cell types. Dynamics of enhancer landscape during early Read more