Utilizing Macrophages Missile for Sulfate-Based Nanomedicine Delivery in Lung Cancer Therapy 

Chang Liu et al.

Research (Wash D C). 2024 Aug 6;7:0448. doi: 10.34133/research.0448. eCollection 2024.

Published on August 7, 2024

Nanomaterial-based drug delivery systems are susceptible to premature drug leakage and systemic toxicity due to lack of specific targeting, and live-cell drug delivery is also Read more

Gene Regulatory Network Analysis of Decidual Stromal Cells and Natural Killer Cells 

Kalle T Rytkönen et al.

Reprod Sci. 2024 Oct;31(10):3159-3174. doi: 10.1007/s43032-024-01653-1. Epub 2024 Aug 1.

Published on August 1, 2024

Human reproductive success relies on the proper differentiation of the uterine endometrium to facilitate implantation, formation of the placenta, and pregnancy. This process involves two Read more

Synaptic proteome perturbations after maternal immune activation: Identification of embryonic and adult hippocampal changes 

Anna Y Yotova et al.

Brain Behav Immun. 2024 Oct;121:351-364. doi: 10.1016/j.bbi.2024.07.040. Epub 2024 Jul 31.

Published on August 1, 2024

CONCLUSIONS: Our data emphasise the dynamic effects of viral-like MIA on developing and mature hippocampi and provide novel targets for study following prenatal immune challenges. Read more

Inferring Tree-Shaped Single-Cell Trajectories with Totem 

António G G Sousa et al.

Methods Mol Biol. 2024;2812:169-191. doi: 10.1007/978-1-0716-3886-6_9.

Published on July 27, 2024

Single-cell transcriptomics allows unbiased characterization of cell heterogeneity in a sample by profiling gene expression at single-cell level. These profiles capture snapshots of transient or Read more

HSV-1 and Cellular miRNAs in CSF-Derived Exosomes as Diagnostically Relevant Biomarkers for Neuroinflammation 

Christian Scheiber et al.

Cells. 2024 Jul 17;13(14):1208. doi: 10.3390/cells13141208.

Published on July 26, 2024

Virus-associated chronic inflammation may contribute to autoimmunity in a number of diseases. In the brain, autoimmune encephalitis appears related to fluctuating reactivation states of neurotropic Read more

The PP2A regulator IER5L supports prostate cancer progression 

Jana R Crespo et al.

Cell Death Dis. 2024 Jul 18;15(7):514. doi: 10.1038/s41419-024-06907-z.

Published on July 18, 2024

Prostate cancer exhibits high prevalence and accounts for a high number of cancer-related deaths. The discovery and characterization of molecular determinants of aggressive prostate cancer Read more

Protocol to study early lung developmental branching in mouse embryos using explant culture 

Salli Talvi et al.

STAR Protoc. 2024 Sep 20;5(3):103198. doi: 10.1016/j.xpro.2024.103198. Epub 2024 Jul 17.

Published on July 18, 2024

Mouse lung branching morphogenesis creates epithelial tree structures required for respiration. Here, we present a protocol for studying mouse lung developmental branching using lung explant Read more

TLNRD1 is a CCM complex component and regulates endothelial barrier integrity 

Neil J Ball et al.

J Cell Biol. 2024 Sep 2;223(9):e202310030. doi: 10.1083/jcb.202310030. Epub 2024 Jul 16.

Published on July 16, 2024

We previously identified talin rod domain-containing protein 1 (TLNRD1) as a potent actin-bundling protein in vitro. Here, we report that TLNRD1 is expressed in the Read more

Identification of an H-Ras nanocluster disrupting peptide 

Candy Laura Steffen et al.

Commun Biol. 2024 Jul 9;7(1):837. doi: 10.1038/s42003-024-06523-9.

Published on July 9, 2024

Hyperactive Ras signalling is found in most cancers. Ras proteins are only active in membrane nanoclusters, which are therefore potential drug targets. We previously showed Read more

Body-wide genetic deficiency of poly(ADP-ribose) polymerase 14 sensitizes mice to colitis 

Madhukar Vedantham et al.

FASEB J. 2024 Jul 15;38(13):e23775. doi: 10.1096/fj.202400484R.

Published on July 5, 2024

Inflammatory bowel disease (IBD) is a chronic disease of the gastrointestinal tract affecting millions of people. Here, we investigated the expression and functions of poly(ADP-ribose) Read more

Multi-omics analysis reveals drivers of loss of β-cell function after newly diagnosed autoimmune type 1 diabetes: An INNODIA multicenter study 

Jose Juan Almagro Armenteros et al.

Diabetes Metab Res Rev. 2024 Jul;40(5):e3833. doi: 10.1002/dmrr.3833.

Published on July 4, 2024

CONCLUSIONS: Features that differ between individuals with slow and rapid decline in β-cell mass could be valuable in staging and prediction of the rate of Read more

Cancer cell invasion alters the protein profile of extracellular vesicles 

Jens C Luoto et al.

J Extracell Biol. 2023 Nov 27;2(12):e124. doi: 10.1002/jex2.124. eCollection 2023 Dec.

Published on June 28, 2024

Extracellular vesicles (EVs) are important mediators of intercellular communication involved in local and long-range signalling of cancer metastasis. The onset of invasion is the key Read more