Navid Delshad et al.Eur J Pharm Sci. 2025 Aug 12:107235. doi: 10.1016/j.ejps.2025.107235. Online ahead of print.Published August 14, 2025
Despite extensive progress in cancer therapeutic research, translating promising anticancer compounds into clinical treatments often fails due to suboptimal pharmacokinetic and safety profiles. These shortcomings... Read more
Stuart Prince et al.Theranostics. 2025 Jun 23;15(15):7501-7527. doi: 10.7150/thno.110544. eCollection 2025.Published August 4, 2025
Rationale: Clever-1 is a multifunctional scavenger receptor that promotes immunosuppressive activity in macrophages, contributing to tumor immune evasion. Its high expression correlates with resistance to... Read more
Katri Vaparanta et al.FEBS J. 2025 Jul 24. doi: 10.1111/febs.70197. Online ahead of print.Published July 24, 2025
The impact of kinase inhibitors on the phosphoproteome has been rarely investigated at a whole-organism level. Here, we performed a phosphoproteomic analysis in embryonic zebrafish... Read more
Edward Chesney et al.Neuropsychopharmacology. 2025 Jul 24. doi: 10.1038/s41386-025-02175-3. Online ahead of print.Published July 23, 2025
In patients with schizophrenia, cannabis use exacerbates symptoms and can lead to a relapse of psychosis. Some experimental studies in healthy volunteers suggest that pre-treatment... Read more
Xi Qiao et al.EMBO Mol Med. 2025 Jul 17. doi: 10.1038/s44321-025-00266-8. Online ahead of print.Published July 17, 2025
In many solid cancer types, surgery alone could be a sufficient first therapy option for a significant number of cancer patients. However, there are currently... Read more
Niklas Z Jäntti et al.Dev Cell. 2025 Jul 9:S1534-5807(25)00403-4. doi: 10.1016/j.devcel.2025.06.025. Online ahead of print.Published July 16, 2025
Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different cancers. The roles... Read more
Sepideh Parvanian et al.Mol Cell Proteomics. 2025 Jul 4:101028. doi: 10.1016/j.mcpro.2025.101028. Online ahead of print.Published July 6, 2025
Epithelial-mesenchymal transition (EMT) is a key biological process in physiological and pathological conditions, spanning development, wound healing, and cancer. Vimentin, a key cytoskeletal intermediate filament... Read more
Afonso Mendes et al.Nat Commun. 2025 Jul 1;16(1):5767. doi: 10.1038/s41467-025-60709-1.Published July 2, 2025
From molecules to organelles, cells exhibit recurring structural motifs across multiple scales. Understanding these structures provides insights into their functional roles. While super-resolution microscopy can... Read more
Itana Bojović et al.Immunol Cell Biol. 2025 Jun 29. doi: 10.1111/imcb.70040. Online ahead of print.Published June 29, 2025
Recent advances in single-cell technologies have enabled the creation of comprehensive cell atlases, reference maps of various cell types within organisms. Here we specifically focus... Read more
Wu Yang et al.J Control Release. 2025 Jun 23:113978. doi: 10.1016/j.jconrel.2025.113978. Online ahead of print.Published June 25, 2025
Critical-sized bone defects present significant clinical challenges due to insufficient stem cell recruitment, epigenetic suppression of osteogenesis, and inadequate mineralization. Among the epigenetic suppression mechanisms,... Read more
John E Eriksson et al.Dev Cell. 2025 Jun 23;60(12):1655-1657. doi: 10.1016/j.devcel.2025.05.015.Published June 24, 2025
In this issue of Developmental Cell, Huang et al. assess the role of vimentin intermediate filaments during extracellular matrix (ECM) degradation by macrophages. Vimentin stabilizes... Read more
