Integrin β1 activity controls colony morphology during human pluripotent stem cell state transitions 

Maria E Taskinen et al.

Stem Cell Reports. 2025 Jun 17:102538. doi: 10.1016/j.stemcr.2025.102538. Online ahead of print.

Published on June 20, 2025

Integrin β1-mediated adhesion is dispensable in early mouse embryogenesis (pre-implantation) but indispensable post-implantation, suggesting distinct roles for β1-integrin-mediated adhesions in the naive (pre-implantation) versus primed Read more

The Next Frontier: Unveiling Novel Approaches for Combating Multidrug-Resistant Bacteria 

Praveen Mallari et al.

Pharm Res. 2025 Jun 16. doi: 10.1007/s11095-025-03871-x. Online ahead of print.

Published on June 16, 2025

CONCLUSION: Despite the substantial obstacles to getting bench findings to the patient, numerous scientists are still working towards this goal. Both the application of antibiotic Read more

A metabolite-based resistance mechanism against malaria 

Ana Figueiredo et al.

Science. 2025 Jun 12;388(6752):eadq6741. doi: 10.1126/science.adq6741. Epub 2025 Jun 12.

Published on June 12, 2025

Jaundice is a common presentation of Plasmodium falciparum malaria, which arises from the accumulation of circulating bilirubin. It is not understood whether it represents an Read more

NRF2-mediated persistent adaptation of oesophageal adenocarcinoma cells to HER2 inhibition 

Wei Zhang et al.

Oncogene. 2025 Jun 5. doi: 10.1038/s41388-025-03459-0. Online ahead of print.

Published on June 5, 2025

The human epidermal growth factor receptor 2 (HER2, also known as ERBB2) is a commonly over-expressed oncoprotein in oesophageal adenocarcinoma (OAC). Nonetheless, HER2-blocking agents have Read more

Biochemical and structural characterization of chlorite dismutase enzyme from Pseudomonas aeruginosa 

Dimitrios V Nokas et al.

FEBS J. 2025 Jun 3. doi: 10.1111/febs.70151. Online ahead of print.

Published on June 3, 2025

Industrialization and urbanization have caused serious contamination of water bodies, and the removal of chemical contaminants has become a major challenge. Chlorite is a harmful Read more

A guide to heat shock factors as multifunctional transcriptional regulators 

Hendrik S E Hästbacka et al.

FEBS J. 2025 Jun 2. doi: 10.1111/febs.70139. Online ahead of print.

Published on June 2, 2025

The heat shock factors (HSFs) form a family of transcription factors, which are evolutionarily conserved in eukaryotes. They are best known as transcriptional regulators of Read more

Proliferation of Human Cervical Cancer Cells Responds to Surface Properties of Bicomponent Polymer Coatings 

Emil Rosqvist et al.

Nanomaterials (Basel). 2025 May 9;15(10):716. doi: 10.3390/nano15100716.

Published on May 27, 2025

The proliferation of human cervical cancer (Hela) cells was investigated on a series of nanostructured polymer latex surfaces. The physico-chemical properties of the surfaces, composed Read more

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells 

James R W Conway et al.

Nat Cell Biol. 2025 May 26. doi: 10.1038/s41556-025-01663-4. Online ahead of print.

Published on May 26, 2025

Integrins provide an essential bridge between cancer cells and the extracellular matrix, playing a central role in every stage of disease progression. Despite the recognized Read more

Mass spectrometric insights into the protein composition of human cutaneous neurofibromas: comparison of neurofibromas with the overlying skin 

Roope A Kallionpää et al.

Br J Cancer. 2025 May 20. doi: 10.1038/s41416-025-03055-9. Online ahead of print.

Published on May 20, 2025

CONCLUSION: The cNFs are relatively quiescent, consistent with their benign nature and limited growth potential. The development of pharmacological therapy for cNFs requires overcoming the Read more

High-resolution live imaging of tardigrade response to anoxia 

Anna-Mari Haapanen-Saaristo et al.

Micron. 2025 May 9;196-197:103847. doi: 10.1016/j.micron.2025.103847. Online ahead of print.

Published on May 14, 2025

Tardigrades are well-known for their ability to tolerate extreme environmental conditions such as heat, drought and lack of oxygen by undergoing cryptobiosis. The molecular responses Read more

CellRomeR: an R package for clustering cell migration phenotypes from microscopy data 

Iivari Kleino et al.

Bioinform Adv. 2025 Apr 4;5(1):vbaf069. doi: 10.1093/bioadv/vbaf069. eCollection 2025.

Published on May 7, 2025

MOTIVATION: The analysis of cell migration using time-lapse microscopy typically focuses on track characteristics for classification and statistical evaluation of migration behaviour. However, considerable heterogeneity Read more

The ERBB2 c.1795C>T, p.Arg599Cys variant is associated with left ventricular outflow tract obstruction defects in humans 

Minna Ampuja et al.

HGG Adv. 2025 May 5;6(3):100446. doi: 10.1016/j.xhgg.2025.100446. Online ahead of print.

Published on May 7, 2025

Non-syndromic congenital heart defects (CHDs) are occasionally familial and left ventricular outflow tract obstruction (LVOTO) defects are among the subtypes with the highest hereditability. The Read more