Publications

    A metabolite-based resistance mechanism against malaria 

    Ana Figueiredo et al.

    Science. 2025 Jun 12;388(6752):eadq6741. doi: 10.1126/science.adq6741. Epub 2025 Jun 12.

    Published on June 12, 2025

    Jaundice is a common presentation of Plasmodium falciparum malaria, which arises from the accumulation of circulating bilirubin. It is not understood whether it represents an Read more

    NRF2-mediated persistent adaptation of oesophageal adenocarcinoma cells to HER2 inhibition 

    Wei Zhang et al.

    Oncogene. 2025 Jun 5. doi: 10.1038/s41388-025-03459-0. Online ahead of print.

    Published on June 5, 2025

    The human epidermal growth factor receptor 2 (HER2, also known as ERBB2) is a commonly over-expressed oncoprotein in oesophageal adenocarcinoma (OAC). Nonetheless, HER2-blocking agents have Read more

    Biochemical and structural characterization of chlorite dismutase enzyme from Pseudomonas aeruginosa 

    Dimitrios V Nokas et al.

    FEBS J. 2025 Jun 3. doi: 10.1111/febs.70151. Online ahead of print.

    Published on June 3, 2025

    Industrialization and urbanization have caused serious contamination of water bodies, and the removal of chemical contaminants has become a major challenge. Chlorite is a harmful Read more

    A guide to heat shock factors as multifunctional transcriptional regulators 

    Hendrik S E Hästbacka et al.

    FEBS J. 2025 Jun 2. doi: 10.1111/febs.70139. Online ahead of print.

    Published on June 2, 2025

    The heat shock factors (HSFs) form a family of transcription factors, which are evolutionarily conserved in eukaryotes. They are best known as transcriptional regulators of Read more

    Proliferation of Human Cervical Cancer Cells Responds to Surface Properties of Bicomponent Polymer Coatings 

    Emil Rosqvist et al.

    Nanomaterials (Basel). 2025 May 9;15(10):716. doi: 10.3390/nano15100716.

    Published on May 27, 2025

    The proliferation of human cervical cancer (Hela) cells was investigated on a series of nanostructured polymer latex surfaces. The physico-chemical properties of the surfaces, composed Read more

    Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells 

    James R W Conway et al.

    Nat Cell Biol. 2025 May 26. doi: 10.1038/s41556-025-01663-4. Online ahead of print.

    Published on May 26, 2025

    Integrins provide an essential bridge between cancer cells and the extracellular matrix, playing a central role in every stage of disease progression. Despite the recognized Read more

    Mass spectrometric insights into the protein composition of human cutaneous neurofibromas: comparison of neurofibromas with the overlying skin 

    Roope A Kallionpää et al.

    Br J Cancer. 2025 May 20. doi: 10.1038/s41416-025-03055-9. Online ahead of print.

    Published on May 20, 2025

    CONCLUSION: The cNFs are relatively quiescent, consistent with their benign nature and limited growth potential. The development of pharmacological therapy for cNFs requires overcoming the Read more

    High-resolution live imaging of tardigrade response to anoxia 

    Anna-Mari Haapanen-Saaristo et al.

    Micron. 2025 May 9;196-197:103847. doi: 10.1016/j.micron.2025.103847. Online ahead of print.

    Published on May 14, 2025

    Tardigrades are well-known for their ability to tolerate extreme environmental conditions such as heat, drought and lack of oxygen by undergoing cryptobiosis. The molecular responses Read more

    CellRomeR: an R package for clustering cell migration phenotypes from microscopy data 

    Iivari Kleino et al.

    Bioinform Adv. 2025 Apr 4;5(1):vbaf069. doi: 10.1093/bioadv/vbaf069. eCollection 2025.

    Published on May 7, 2025

    MOTIVATION: The analysis of cell migration using time-lapse microscopy typically focuses on track characteristics for classification and statistical evaluation of migration behaviour. However, considerable heterogeneity Read more

    The ERBB2 c.1795C>T, p.Arg599Cys variant is associated with left ventricular outflow tract obstruction defects in humans 

    Minna Ampuja et al.

    HGG Adv. 2025 May 5;6(3):100446. doi: 10.1016/j.xhgg.2025.100446. Online ahead of print.

    Published on May 7, 2025

    Non-syndromic congenital heart defects (CHDs) are occasionally familial and left ventricular outflow tract obstruction (LVOTO) defects are among the subtypes with the highest hereditability. The Read more

    HDAC1 is involved in the destabilization of the HSF2 protein under non-stress and stress conditions 

    Kevin Daupin et al.

    Cell Stress Chaperones. 2025 May 1:100079. doi: 10.1016/j.cstres.2025.100079. Online ahead of print.

    Published on May 3, 2025

    Heat shock transcription factors 1 and 2 (HSF1 and HSF2) are the major regulators of the cellular response to stressors, notably to heat shock and Read more

    Longitudinal pathway analysis using structural information with case studies in early type 1 diabetes 

    Maria K Jaakkola et al.

    Sci Rep. 2025 May 2;15(1):15393. doi: 10.1038/s41598-025-98492-0.

    Published on May 2, 2025

    Pathway analysis is a frequent step in studies involving gene or protein expression data, but most of the available pathway methods are designed for simple Read more