Biomineralize Mitochondria in Metal-Organic Frameworks to Promote Mitochondria Transplantation From Non-Tumorigenic Cells Into Cancer Cells 

Jun-Nian Zhou et al.

Smart Med. 2025 Feb 26;4(1):e134. doi: 10.1002/smmd.134. eCollection 2025 Mar.

Published on March 10, 2025

Mitochondria are crucial to cellular physiology, and growing evidence highlights the significant impact of mitochondrial dysfunction in diabetes, aging, neurodegenerative disorders, and cancers. Therefore, mitochondrial Read more

Risk of early death after treatment with curative intent for head and neck squamous cell carcinoma: a retrospective population-based study 

Mahmoud Bazina et al.

Acta Oncol. 2025 Mar 4;64:339-348. doi: 10.2340/1651-226X.2025.42202.

Published on March 4, 2025

BACKGROUND AND PURPOSE: Knowledge regarding the risk factors for early death in patients with head and neck squamous cell carcinoma (HNSCC) is scarce. This study Read more

A new rapid lipoarabinomannan urine assay for tuberculosis: a two-centre diagnostic accuracy evaluation in outpatients with and without HIV 

Beston Hamasur et al.

Res Sq [Preprint]. 2025 Feb 18:rs.3.rs-5386988. doi: 10.21203/rs.3.rs-5386988/v2.

Published on March 4, 2025

CONCLUSIONS: BP-LAM has higher sensitivity than LF-LAM, including in HIV-negative people, potentially permitting the expansion of urine LAM testing beyond people with advanced immunosuppression.

Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes affirms markers of disease 

Robert Moulder et al.

Diabetologia. 2025 Jun;68(6):1108-1114. doi: 10.1007/s00125-025-06394-7. Epub 2025 Feb 28.

Published on February 28, 2025

CONCLUSIONS/INTERPRETATION: The validated results reflect the landscape of biological changes accompanying type 1 diabetes. For example, the association of the targeted apolipoproteins with fasting C-peptide/glucose Read more

Added value of HPV-DNA in situ hybridization as an adjunct to p16 Immunohistochemistry in oropharyngeal squamous cell carcinoma 

Linda Nissi et al.

Acta Otolaryngol. 2025 Apr;145(4):340-347. doi: 10.1080/00016489.2025.2461653. Epub 2025 Feb 10.

Published on February 10, 2025

CONCLUSIONS AND SIGNIFICANCE: Both p16 IHC and HPV-DNA ISH perform well as separate prognostic biomarkers for OS, DSS, and DFS on a population level. However, Read more

Exploring the physicochemical interactions and loading strategies of mesoporous silicon dioxide nanoparticles for drug delivery 

Svetlana Yu Kovtareva et al.

Eur J Pharm Biopharm. 2025 Mar;208:114654. doi: 10.1016/j.ejpb.2025.114654. Epub 2025 Feb 3.

Published on February 5, 2025

Mesoporous silica nanoparticles play an important role in drug delivery due to their high surface area, porous structure, tunable pore size, chemical stability and functionalization Read more

Nuclear talin-1 provides a bridge between cell adhesion and gene expression 

Alejandro J Da Silva et al.

iScience. 2025 Jan 4;28(2):111745. doi: 10.1016/j.isci.2025.111745. eCollection 2025 Feb 21.

Published on February 3, 2025

Talin-1 (TLN1) is best known to activate integrin receptors and transmit mechanical stimuli to the actin cytoskeleton at focal adhesions. However, the localization of TLN1 Read more

Liquid and gas-chromatography-mass spectrometry methods for exposome analysis 

Victor Castro-Alves et al.

J Chromatogr A. 2025 Mar 15;1744:465728. doi: 10.1016/j.chroma.2025.465728. Epub 2025 Jan 25.

Published on February 2, 2025

Mass spectrometry-based methods have become fundamental to exposome research, providing the capability to explore a broad spectrum of chemical exposures. Liquid and gas chromatography coupled Read more

Metaproteomics Beyond Databases: Addressing the Challenges and Potentials of De Novo Sequencing 

Tim Van Den Bossche et al.

Proteomics. 2025 Jan 31:e202400321. doi: 10.1002/pmic.202400321. Online ahead of print.

Published on January 31, 2025

Metaproteomics enables the large-scale characterization of microbial community proteins, offering crucial insights into their taxonomic composition, functional activities, and interactions within their environments. By directly Read more

Adaptive sequence alignment for metagenomic data analysis 

Sami Pietilä et al.

Comput Biol Med. 2025 Mar;186:109743. doi: 10.1016/j.compbiomed.2025.109743. Epub 2025 Jan 26.

Published on January 27, 2025

With advances in sequencing technologies, the use of high-throughput sequencing to characterize microbial communities is becoming increasingly feasible. However, metagenomic assembly poses computational challenges in Read more

Dual physiological responsive structural color hydrogel particles for wound repair 

Li Wang et al.

Bioact Mater. 2025 Jan 7;46:494-502. doi: 10.1016/j.bioactmat.2025.01.002. eCollection 2025 Apr.

Published on January 27, 2025

Hydrogel-based patches have demonstrated their values in diabetic wounds repair, particularly those intelligent dressings with continuous repair promoting and monitoring capabilities. Here, we propose a Read more

Mechanically regulated microcarriers with stem cell loading for skin photoaging therapy 

Xiang Lin et al.

Bioact Mater. 2025 Jan 3;46:448-456. doi: 10.1016/j.bioactmat.2024.12.024. eCollection 2025 Apr.

Published on January 24, 2025

Long-term exposure to ultraviolet radiation compromises skin structural integrity and results in disruption of normal physiological functions. Stem cells have gained attention in anti-photoaging, while Read more