Publications

    PUBLICATION

    Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells 

    James R W Conway et al.

    Nat Cell Biol. 2025 May 26. doi: 10.1038/s41556-025-01663-4. Online ahead of print.

    Published on May 26, 2025

    Integrins provide an essential bridge between cancer cells and the extracellular matrix, playing a central role in every stage of disease progression. Despite the recognized Read more

    PUBLICATION

    Mass spectrometric insights into the protein composition of human cutaneous neurofibromas: comparison of neurofibromas with the overlying skin 

    Roope A Kallionpää et al.

    Br J Cancer. 2025 May 20. doi: 10.1038/s41416-025-03055-9. Online ahead of print.

    Published on May 20, 2025

    CONCLUSION: The cNFs are relatively quiescent, consistent with their benign nature and limited growth potential. The development of pharmacological therapy for cNFs requires overcoming the Read more

    PUBLICATION

    High-resolution live imaging of tardigrade response to anoxia 

    Anna-Mari Haapanen-Saaristo et al.

    Micron. 2025 May 9;196-197:103847. doi: 10.1016/j.micron.2025.103847. Online ahead of print.

    Published on May 14, 2025

    Tardigrades are well-known for their ability to tolerate extreme environmental conditions such as heat, drought and lack of oxygen by undergoing cryptobiosis. The molecular responses Read more

    PUBLICATION

    CellRomeR: an R package for clustering cell migration phenotypes from microscopy data 

    Iivari Kleino et al.

    Bioinform Adv. 2025 Apr 4;5(1):vbaf069. doi: 10.1093/bioadv/vbaf069. eCollection 2025.

    Published on May 7, 2025

    MOTIVATION: The analysis of cell migration using time-lapse microscopy typically focuses on track characteristics for classification and statistical evaluation of migration behaviour. However, considerable heterogeneity Read more

    PUBLICATION

    The ERBB2 c.1795C>T, p.Arg599Cys variant is associated with left ventricular outflow tract obstruction defects in humans 

    Minna Ampuja et al.

    HGG Adv. 2025 May 5;6(3):100446. doi: 10.1016/j.xhgg.2025.100446. Online ahead of print.

    Published on May 7, 2025

    Non-syndromic congenital heart defects (CHDs) are occasionally familial and left ventricular outflow tract obstruction (LVOTO) defects are among the subtypes with the highest hereditability. The Read more

    PUBLICATION

    HDAC1 is involved in the destabilization of the HSF2 protein under non-stress and stress conditions 

    Kevin Daupin et al.

    Cell Stress Chaperones. 2025 May 1:100079. doi: 10.1016/j.cstres.2025.100079. Online ahead of print.

    Published on May 3, 2025

    Heat shock transcription factors 1 and 2 (HSF1 and HSF2) are the major regulators of the cellular response to stressors, notably to heat shock and Read more

    PUBLICATION

    Longitudinal pathway analysis using structural information with case studies in early type 1 diabetes 

    Maria K Jaakkola et al.

    Sci Rep. 2025 May 2;15(1):15393. doi: 10.1038/s41598-025-98492-0.

    Published on May 2, 2025

    Pathway analysis is a frequent step in studies involving gene or protein expression data, but most of the available pathway methods are designed for simple Read more

    PUBLICATION

    Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes 

    Emil Hiitola et al.

    Sci Adv. 2025 May 2;11(18):eadt9846. doi: 10.1126/sciadv.adt9846. Epub 2025 Apr 30.

    Published on April 30, 2025

    Clonal hematopoiesis (CH) becomes more prevalent with aging and may influence inflammatory diseases by altering immune function. While CH of indeterminate potential (CHIP) promotes inflammation Read more

    PUBLICATION

    Evaluation of Integrin Glycovariants as Biomarkers of Metastasis, Invasion, and Therapy Stratification in Head and Neck Squamous Cell Carcinoma 

    Erica Routila et al.

    Cancer Med. 2025 May;14(9):e70717. doi: 10.1002/cam4.70717.

    Published on April 27, 2025

    CONCLUSIONS: We demonstrate that while integrin glycovariants are abundant in HNSCC tumors and ITGB1-WFL was associated with invasiveness, integrin glycovariants do not directly correlate with Read more

    PUBLICATION

    Novel Genetic Risk Variants Associated with Oral Tongue Squamous Cell Carcinoma 

    Rayan Nikkilä et al.

    Head Neck Pathol. 2025 Apr 25;19(1):45. doi: 10.1007/s12105-025-01784-0.

    Published on April 25, 2025

    CONCLUSION: The GWAS detected two novel genetic associations with OTSCC. Further research is needed to identify the genes at these loci that contribute to the Read more

    PUBLICATION

    Heat shock factor 2 regulates oncogenic gamma-herpesvirus gene expression by remodeling the chromatin at the ORF50 and BZLF1 promoter 

    Lorenza Cutrone et al.

    PLoS Pathog. 2025 Apr 17;21(4):e1013108. doi: 10.1371/journal.ppat.1013108. eCollection 2025 Apr.

    Published on April 17, 2025

    The Human gamma-herpesviruses Kaposi's sarcoma herpesvirus (KSHV) and Epstein-Barr virus (EBV) are causally associated to a wide range of cancers. While the default infection program Read more

    PUBLICATION

    Histological tumor necrosis predicts decreased survival after neoadjuvant chemotherapy in head and neck squamous cell carcinoma 

    A R Koskenniemi et al.

    Oral Oncol. 2025 Jun;165:107287. doi: 10.1016/j.oraloncology.2025.107287. Epub 2025 Apr 16.

    Published on April 17, 2025

    CONCLUSIONS: Detection of tumor necrosis and AI-driven deep learning effectively predict neoadjuvant RT/CRT responses in HNSCC.