Publications

A new rapid lipoarabinomannan urine assay for tuberculosis: a two-centre diagnostic accuracy evaluation in outpatients with and without HIV

Beston Hamasur et al.

Res Sq [Preprint]. 2025 Feb 18:rs.3.rs-5386988. doi: 10.21203/rs.3.rs-5386988/v2.

CONCLUSIONS: BP-LAM has higher sensitivity than LF-LAM, including in HIV-negative people, potentially permitting the expansion of urine LAM testing beyond people with advanced immunosuppression.

Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes affirms markers of disease

Robert Moulder et al.

Diabetologia. 2025 Jun;68(6):1108-1114. doi: 10.1007/s00125-025-06394-7. Epub 2025 Feb 28.

CONCLUSIONS/INTERPRETATION: The validated results reflect the landscape of biological changes accompanying type 1 diabetes. For example, the association of the targeted apolipoproteins with fasting C-peptide/glucose ratios in the first year after diagnosis is likely to relate to lipid abnormalities observed in individuals with type 1 diabetes, and reiterates the connection of apolipoproteins with the underlying changes accompanying the disease. Further research is needed to explore the clinical...

Added value of HPV-DNA in situ hybridization as an adjunct to p16 Immunohistochemistry in oropharyngeal squamous cell carcinoma

Linda Nissi et al.

Acta Otolaryngol. 2025 Apr;145(4):340-347. doi: 10.1080/00016489.2025.2461653. Epub 2025 Feb 10.

CONCLUSIONS AND SIGNIFICANCE: Both p16 IHC and HPV-DNA ISH perform well as separate prognostic biomarkers for OS, DSS, and DFS on a population level. However, a discordant group does exist. Limiting HPV-DNA testing for p16-positive patients who smoke by the time of diagnosis may be a cost-efficient and justified solution.

Exploring the physicochemical interactions and loading strategies of mesoporous silicon dioxide nanoparticles for drug delivery

Svetlana Yu Kovtareva et al.

Eur J Pharm Biopharm. 2025 Mar;208:114654. doi: 10.1016/j.ejpb.2025.114654. Epub 2025 Feb 3.

Mesoporous silica nanoparticles play an important role in drug delivery due to their high surface area, porous structure, tunable pore size, chemical stability and functionalization capability. Such properties make them a good candidate for drug encapsulation. However, molecular binding is another parameter that govern drug loading apart of pores' structure and size. There is a lack of comprehensive reviews on that topic nowadays. This paper overviews the latest publications on the...

Nuclear talin-1 provides a bridge between cell adhesion and gene expression

Alejandro J Da Silva et al.

iScience. 2025 Jan 4;28(2):111745. doi: 10.1016/j.isci.2025.111745. eCollection 2025 Feb 21.

Talin-1 (TLN1) is best known to activate integrin receptors and transmit mechanical stimuli to the actin cytoskeleton at focal adhesions. However, the localization of TLN1 is not restricted to focal adhesions. By utilizing both subcellular fractionations and confocal microscopy analyses, we show that TLN1 localizes to the nucleus in several human cell lines, where it is tightly associated with the chromatin. Importantly, small interfering RNA (siRNA)-mediated depletion of endogenous TLN1...

Liquid and gas-chromatography-mass spectrometry methods for exposome analysis

Victor Castro-Alves et al.

J Chromatogr A. 2025 Mar 15;1744:465728. doi: 10.1016/j.chroma.2025.465728. Epub 2025 Jan 25.

Mass spectrometry-based methods have become fundamental to exposome research, providing the capability to explore a broad spectrum of chemical exposures. Liquid and gas chromatography coupled with low/high-resolution mass spectrometry (MS) are among the most frequently employed platforms due to their sensitivity and accuracy. However, these approaches present challenges, such as the inherent complexity of MS data and the expertise of biologists, chemists, clinicians, and data analysts to...