Publications
Dual physiological responsive structural color hydrogel particles for wound repair
Bioact Mater. 2025 Jan 7;46:494-502. doi: 10.1016/j.bioactmat.2025.01.002. eCollection 2025 Apr.
Published on January 27, 2025
Mechanically regulated microcarriers with stem cell loading for skin photoaging therapy
Bioact Mater. 2025 Jan 3;46:448-456. doi: 10.1016/j.bioactmat.2024.12.024. eCollection 2025 Apr.
Published on January 24, 2025
Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance
Cell Rep. 2025 Feb 25;44(2):115227. doi: 10.1016/j.celrep.2024.115227. Epub 2025 Jan 21.
Published on January 22, 2025
Microfluidics-enabled core/shell nanostructure assembly: Understanding encapsulation processes via particle characterization and molecular dynamics
Adv Colloid Interface Sci. 2025 Apr;338:103400. doi: 10.1016/j.cis.2025.103400. Epub 2025 Jan 12.
Published on January 17, 2025
There Goes the Neighbourhood-A Multi-City Study Reveals Ticks and Tick-Borne Pathogens Commonly Occupy Urban Green Spaces
Zoonoses Public Health. 2025 May;72(3):313-323. doi: 10.1111/zph.13208. Epub 2025 Jan 16.
Published on January 17, 2025
Proteomic profiling reveals alterations in metabolic and cellular pathways in severe obesity and following metabolic bariatric surgery
Am J Physiol Endocrinol Metab. 2025 Mar 1;328(3):E311-E324. doi: 10.1152/ajpendo.00220.2024. Epub 2025 Jan 17.
Published on January 17, 2025
Efficiently accelerated bioimage analysis with NanoPyx, a Liquid Engine-powered Python framework
Nat Methods. 2025 Feb;22(2):283-286. doi: 10.1038/s41592-024-02562-6. Epub 2025 Jan 2.
Published on January 2, 2025
Harnessing artificial intelligence to reduce phototoxicity in live imaging
Fluorescence microscopy is essential for studying living cells, tissues and organisms. However, the fluorescent light that switches on fluorescent molecules also harms the samples, jeopardizing the validity of results - particularly in techniques such as super-resolution microscopy, which demands extended illumination. Artificial intelligence (AI)-enabled software capable of denoising, image restoration, temporal interpolation or cross-modal style transfer has great potential to rescue live imaging data and limit photodamage. Yet we believe the focus should be on maintaining light-induced damage at levels that preserve natural cell behaviour. In this Opinion piece, we argue that a shift in role for AIs is needed - AI should be used to extract rich insights from gentle imaging rather than recover compromised data from harsh illumination. Although AI can enhance imaging, our ultimate goal should be to uncover biological truths, not just retrieve data. It is essential to prioritize minimizing photodamage over merely pushing technical limits. Our approach is aimed towards gentle acquisition and observation of undisturbed living systems, aligning with the essence of live-cell fluorescence microscopy.
Published on December 27, 2024
AXL-TBK1 driven AKT3 activation promotes metastasis
Sci Signal. 2024 Dec 17;17(867):eado6057. doi: 10.1126/scisignal.ado6057. Epub 2024 Dec 17.
Published on December 17, 2024
Engineering and Targeting Neutrophils for Cancer Therapy
Neutrophils are the most abundant white blood cells in the circulation and act as the first line of defense against infections. Increasing evidence suggests that neutrophils possess heterogeneous phenotypes and functional plasticity in human health and diseases, including cancer. Neutrophils play multifaceted roles in cancer development and progression, and an N1/N2 paradigm of neutrophils in cancer is proposed, where N1 neutrophils exert anti-tumor properties while N2 neutrophils display tumor-supportive and immune-suppressive functions. Selective activation of beneficial neutrophil population and targeted inhibition or re-polarization of tumor-promoting neutrophils has shown an important potential in tumor therapy. In addition, due to the natural inflammation-responsive and physical barrier-crossing abilities, neutrophils and their derivatives (membranes and extracellular vesicles (EVs)) are regarded as advanced drug delivery carriers for enhanced tumor targeting and improved therapeutic efficacy. In this review, the recent advances in engineering neutrophils for drug delivery and targeting neutrophils for remodeling tumor microenvironment (TME) are comprehensively presented. This review will provide a broad understanding of the potential of neutrophils in cancer therapy.
Published on December 10, 2024
Stress biology: Complexity and multifariousness in health and disease
Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. Sixty-one years after the discovery of the heat shock response by Ferruccio Ritossa, many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperones was reported at the 12th International Symposium on Heat Shock Proteins in Biology, Medicine and the Environment in the Old Town Alexandria, VA, USA from 28th to 31st of October 2023.
Published on December 10, 2024
Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality in mice
Embigin (Gp70), a receptor for fibronectin and an ancillary protein for monocarboxylate transporters, is known to regulate stem cell niches in sebaceous gland and bone marrow. Here, we show that embigin expression is at high level during early mouse embryogenesis and that embigin is essential for lung development. Markedly increased neonatal mortality of Emb-/- mice can be explained by the compromised lung maturation: in Emb-/- mice (E17.5) the number and the size of the small airways and distal airspace are significantly smaller, there are fewer ATI and ATII cells, and the alkaline phosphatase activity in amniotic fluid is lower. Emb-/- lungs show less peripheral branching already at E12.5, and embigin is highly expressed in lung primordium. Thus, embigin function is essential at early pseudoglandular stage or even earlier. Furthermore, our RNA-seq analysis and Ki67 staining results support the idea that the development of Emb-/- lungs is rather delayed than defected.
Published on December 10, 2024