Publications

    Publication
    Characterization of Visceral Adipose Tissue Proteome Reveals Metabolic Changes and Inflammatory Signatures in Severe Obesity 
    Prince Dadson et al. Obesity (Silver Spring). 2025 Oct 12. doi: 10.1002/oby.70041. Online ahead of print. Published October 12, 2025
    CONCLUSIONS: These findings demonstrate significant molecular alterations in the VAT proteome associated with severe obesity, providing insights into the underlying mechanisms of metabolic disease. The... Read more
    Publication
    Prenatal exposure to perfluoroalkyl substances predicts multimodal brain structural and functional outcomes in children aged 5 years: a birth cohort study 
    Aaron Barron et al. Lancet Planet Health. 2025 Oct 9:101309. doi: 10.1016/j.lanplh.2025.101309. Online ahead of print. Published October 12, 2025
    BACKGROUND: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are ubiquitous persistent organic pollutants associated with adverse health outcomes in humans. Although they are associated with autism spectrum... Read more
    Publication
    LimROTS: A Hybrid Method Integrating Empirical Bayes and Reproducibility-Optimized Statistics for Robust Differential Expression Analysis 
    Ali Mostafa Anwara et al. Bioinformatics. 2025 Oct 11:btaf570. doi: 10.1093/bioinformatics/btaf570. Online ahead of print. Published October 11, 2025
    MOTIVATION: Differential expression analysis plays a vital role in omics research enabling precise identification of features that associate with different phenotypes. This process is critical... Read more
    Publication
    MicroRNA gene dynamics in immune cell subpopulations during aging and atherosclerosis disease development at single-cell resolution 
    Ana Hernández de Sande et al. Genome Med. 2025 Oct 6;17(1):112. doi: 10.1186/s13073-025-01530-9. Published October 7, 2025
    CONCLUSIONS: We demonstrate that miRNA gene transcriptional activity is widely impacted in immune cells by aging and during disease development and further identify the corresponding... Read more
    Publication
    Functional characterization and directed evolution of Cicer arietinum glutathione transferases for enhanced hydroperoxidase activity and ligandin function 
    Anni Kontouri et al. Phytochemistry. 2025 Sep 27;242:114692. doi: 10.1016/j.phytochem.2025.114692. Online ahead of print. Published September 29, 2025
    Tau class glutathione transferases (GSTUs) play essential roles in plant defense by facilitating the nucleophilic attack of glutathione (GSH) to a wide range of electrophilic... Read more
    Publication
    Early life gut microbial and metabolic shifts reflected in stool consistency- a gut transit time proxy 
    Anna-Katariina Aatsinki et al. bioRxiv [Preprint]. 2025 Sep 16:2024.06.05.597641. doi: 10.1101/2024.06.05.597641. Published September 26, 2025
    Transit time, fluid intake, diet, and overall gut health all influence stool consistency. However, the relationships between the gut microbiota, metabolome (microbial metabolites), and stool... Read more
    Publication
    Anisomelic acid promotes proteasomal degradation of HPV16 E6 via E3 ligase recruitment: A mass spectrometry-based interactome study 
    Michael Santos Silva et al. J Proteomics. 2025 Sep 16;322:105536. doi: 10.1016/j.jprot.2025.105536. Online ahead of print. Published September 18, 2025
    Human papillomavirus (HPV) is a major driver of cervical and other epithelial cancers, with the viral oncoprotein E6 playing a central role in tumorigenesis by... Read more
    Publication
    HSF2 drives breast cancer progression by acting as a stage-specific switch between proliferation and invasion 
    Jenny C Pessa et al. Sci Adv. 2025 Sep 5;11(36):eady1289. doi: 10.1126/sciadv.ady1289. Epub 2025 Sep 3. Published September 3, 2025
    Breast cancer is hallmarked by phenotypic transitions enabling abnormal cell proliferation and invasion. The stress-protective transcription factor heat shock factor 2 (HSF2) is associated with... Read more
    Publication
    Breast Milk Proteome: Changes in the Different Stages of Lactation and Impacts of Gestational Diabetes Mellitus and Body Mass Index 
    Timo Seitz et al. Mol Nutr Food Res. 2025 Sep 1:e70225. doi: 10.1002/mnfr.70225. Online ahead of print. Published September 2, 2025
    Breast milk proteome comprises hundreds of bioactive proteins supporting infant development. The extent to which maternal metabolic conditions modify the proteome is poorly known. This... Read more
    Publication
    Metabolome informs about the chemical exposome and links to brain health 
    Matej Orešič et al. Environ Int. 2025 Aug 22;203:109741. doi: 10.1016/j.envint.2025.109741. Online ahead of print. Published September 1, 2025
    The metabolome is an intermediate phenotype, summarizing the profile of all small molecules ( Read more
    Publication
    Designing Fluorescent Estrogen Mimetic 7-hydroxycoumarin Probe Substrates for Human Sulfotransferase Enzymes 
    Risto O Juvonen et al. Eur J Pharm Sci. 2025 Aug 28:107249. doi: 10.1016/j.ejps.2025.107249. Online ahead of print. Published August 30, 2025
    Sulfonation is one of drug metabolism reactions affecting homeostasis of estrogens. C-3 aryl substituted 7-hydroxycoumarins are fluorescent estrogen mimetics; i.e., the hydroxyl groups of both... Read more
    Publication
    Cholesterol Ester Storage Disease in Two Field Spaniels With Lysosomal Acid Lipase Deficiency 
    Pernilla Syrjä et al. J Vet Intern Med. 2025 Sep-Oct;39(5):e70223. doi: 10.1111/jvim.70223. Published August 27, 2025
    Cholesterol ester storage disease (CESD) is a rare genetic lysosomal storage disorder resulting from lower lysosomal acid lipase (LAL) activity. LAL is an essential enzyme... Read more
    Last updated on June 25, 2025