Publications

    Glutaraldehyde-enhanced autofluorescence as a general tool for 3D morphological imaging 

    Miika Niemeläinen et al.

    Biol Open. 2024 Nov 15;13(11):bio060428. doi: 10.1242/bio.060428. Epub 2024 Nov 11.

    Published on October 21, 2024

    Routine histochemical techniques are capable of producing vast amount of information from diverse sample types, but these techniques are limited in their ability to generate Read more

    Empirically establishing drug exposure records directly from untargeted metabolomics data 

    Haoqi Nina Zhao et al.

    bioRxiv [Preprint]. 2024 Oct 26:2024.10.07.617109. doi: 10.1101/2024.10.07.617109.

    Published on October 17, 2024

    Despite extensive efforts, extracting information on medication exposure from clinical records remains challenging. To complement this approach, we developed the tandem mass spectrometry (MS/MS) based Read more

    Detection of Tn-antigen in breast and prostate cancer models by VVL-labeled red dye-doped nanoparticles 

    Alejandra Verhassel et al.

    Nanomedicine (Lond). 2024;19(29):2463-2478. doi: 10.1080/17435889.2024.2405454. Epub 2024 Oct 9.

    Published on October 9, 2024

    Aim: Fluorescence detection of breast and prostate cancer cells expressing Tn-antigen, a tumor marker, with Vicia villosa lectin (VVL)-labeled nanoparticles.Materials & methods: Breast and prostate Read more

    Restoring mechanophenotype reverts malignant properties of ECM-enriched vocal fold cancer 

    Jasmin Kaivola et al.

    bioRxiv [Preprint]. 2024 Aug 23:2024.08.22.609159. doi: 10.1101/2024.08.22.609159.

    Published on October 7, 2024

    Increased extracellular matrix (ECM) and matrix stiffness promote solid tumor progression. However, mechanotransduction in cancers arising in mechanically active tissues remains underexplored. Here, we report Read more

    Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards 

    Federico Torta et al.

    Nat Commun. 2024 Oct 3;15(1):8562. doi: 10.1038/s41467-024-52087-x.

    Published on October 3, 2024

    In this community effort, we compare measurements between 34 laboratories from 19 countries, utilizing mixtures of labelled authentic synthetic standards, to quantify by mass spectrometry Read more

    The role and regulation of integrins in cell migration and invasion 

    Megan R Chastney et al.

    Nat Rev Mol Cell Biol. 2025 Feb;26(2):147-167. doi: 10.1038/s41580-024-00777-1. Epub 2024 Sep 30.

    Published on September 30, 2024

    Integrin receptors are the main molecular link between cells and the extracellular matrix (ECM) as well as mediating cell-cell interactions. Integrin-ECM binding triggers the formation Read more

    Profiling steroid hormone landscape of bladder cancer reveals depletion of intratumoural androgens to castration levels: a cross-sectional study 

    Kimmo Kettunen et al.

    EBioMedicine. 2024 Oct;108:105359. doi: 10.1016/j.ebiom.2024.105359. Epub 2024 Sep 28.

    Published on September 29, 2024

    BACKGROUND: Bladder cancer is a highly over-represented disease in males. The involvement of sex steroids in bladder carcinogenesis and the utilisation of steroid hormone action Read more

    Empagliflozin attenuates hypoxia-induced heart failure of zebrafish embryos via influencing MMP13 expression 

    R Huttunen et al.

    Biomed Pharmacother. 2024 Nov;180:117453. doi: 10.1016/j.biopha.2024.117453. Epub 2024 Sep 26.

    Published on September 27, 2024

    CONCLUSIONS: Our study shows that empagliflozin´s favorable effect on attenuating HF is mediated via MMP13. MMP13 provides a novel option when developing new therapeutics for Read more

    IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis 

    Peng Zhang et al.

    Cell Metab. 2024 Oct 1;36(10):2341-2354.e6. doi: 10.1016/j.cmet.2024.08.012. Epub 2024 Sep 23.

    Published on September 24, 2024

    The exponential rise in metabolic dysfunction-associated steatotic liver disease (MASLD) parallels the ever-increasing consumption of energy-dense diets, underscoring the need for effective MASLD-resolving drugs. MASLD Read more

    Atomistic simulations reveal impacts of missense mutations on the structure and function of SynGAP1 

    Aliaa E Ali et al.

    Brief Bioinform. 2024 Sep 23;25(6):bbae458. doi: 10.1093/bib/bbae458.

    Published on September 23, 2024

    De novo mutations in the synaptic GTPase activating protein (SynGAP) are associated with neurological disorders like intellectual disability, epilepsy, and autism. SynGAP is also implicated Read more

    Single-cell transcriptome analysis of the early immune response in the lymph nodes of Borrelia burgdorferi-infected mice 

    Varpu Rinne et al.

    Microbes Infect. 2025 Feb;27(2):105424. doi: 10.1016/j.micinf.2024.105424. Epub 2024 Sep 19.

    Published on September 21, 2024

    Lyme borreliosis is a disease caused by Borrelia burgdorferi sensu lato bacteria. Borrelia burgdorferi is known to induce prolonged extrafollicular immune responses and abnormal germinal Read more

    Proteomic profiling identifies a direct interaction between heat shock transcription factor 2 and the focal adhesion adapter talin-1 

    Alejandro J Da Silva et al.

    FEBS J. 2024 Nov;291(21):4830-4848. doi: 10.1111/febs.17271. Epub 2024 Sep 16.

    Published on September 17, 2024

    Heat shock factor 2 (HSF2) is a versatile transcription factor that regulates gene expression under stress conditions, during development, and in disease. Despite recent advances Read more