Chondroitin Sulfate-Coated Heteroduplex-Molecular Spherical Nucleic Acids 

Toni Laine et al.

Chembiochem. 2025 Mar 15;26(6):e202400908. doi: 10.1002/cbic.202400908. Epub 2024 Nov 28.

Published on November 15, 2024

Molecular Spherical Nucleic Acids (MSNAs) are atomically uniform dendritic nanostructures and potential delivery vehicles for oligonucleotides. The radial formulation combined with covalent conjugation may hide Read more

Comparative analysis of the postadmission and antemortem oropharyngeal and rectal swab microbiota of ICU patients 

Annamaria Petrilla et al.

Sci Rep. 2024 Nov 8;14(1):27179. doi: 10.1038/s41598-024-78102-1.

Published on November 8, 2024

Shotgun metabarcoding was conducted to examine the microbiota in a total of 48 samples from 12 critically ill patients, analyzing samples from both the oropharynx Read more

The Proteomics Standards Initiative Standardized Formats for Spectral Libraries and Fragment Ion Peak Annotations: mzSpecLib and mzPAF 

Joshua Klein et al.

Anal Chem. 2024 Nov 19;96(46):18491-18501. doi: 10.1021/acs.analchem.4c04091. Epub 2024 Nov 8.

Published on November 8, 2024

Mass spectral libraries are collections of reference spectra, usually associated with specific analytes from which the spectra were generated, that are used for further downstream Read more

Expanding the Molecular and Clinical Phenotype of Patients With De Novo Variants in KIF5C: A Six Patient Case Series 

Sara Gracie et al.

Am J Med Genet A. 2025 Mar;197(3):e63927. doi: 10.1002/ajmg.a.63927. Epub 2024 Nov 6.

Published on November 6, 2024

Heterozygous de novo loss of function variants in the motor domain of KIF5C are associated with a neurodevelopmental disorder characterized by infantile-onset epilepsy, frontal cortical Read more

Multiplatform metabolomic interlaboratory study of a whole human stool candidate reference material from omnivore and vegan donors 

Abraham Kuri Cruz et al.

Metabolomics. 2024 Nov 4;20(6):125. doi: 10.1007/s11306-024-02185-0.

Published on November 4, 2024

CONCLUSION: This collaborative exercise emphasized the broad chemical survey possible with multi-technique approaches. Community engagement is essential for the evaluation and characterization of common materials Read more

xCT as a Predictor for Survival in a Population-Based Cohort of Head and Neck Squamous Cell Carcinoma 

Linda Nissi et al.

Cancer Med. 2024 Nov;13(21):e70371. doi: 10.1002/cam4.70371.

Published on November 2, 2024

CONCLUSIONS: High xCT expression was associated with poor prognosis in OPSCC. Our findings suggest that joint analysis of xCT and p16 may add significant value Read more

Structural Repetition Detector: multi-scale quantitative mapping of molecular complexes through microscopy 

Afonso Mendes et al.

Res Sq [Preprint]. 2024 Oct 15:rs.3.rs-5182329. doi: 10.21203/rs.3.rs-5182329/v1.

Published on November 1, 2024

From molecules to organelles, cells exhibit recurring structural motifs across multiple scales. Understanding these structures provides insights into their functional roles. While superresolution microscopy can Read more

Imaging cell architecture and dynamics 

Lucy Collinson et al.

J Cell Sci. 2024 Oct 15;137(20):jcs263575. doi: 10.1242/jcs.263575. Epub 2024 Oct 30.

Published on October 30, 2024

No abstract

Multiparameter imaging reveals clinically relevant cancer cell-stroma interaction dynamics in head and neck cancer 

Karolina Punovuori et al.

Cell. 2024 Dec 12;187(25):7267-7284.e20. doi: 10.1016/j.cell.2024.09.046. Epub 2024 Oct 28.

Published on October 29, 2024

Epithelial tumors are characterized by abundant inter- and intra-tumor heterogeneity, which complicates diagnostics and treatment. The contribution of cancer-stroma interactions to this heterogeneity is poorly Read more

Encapsulated mitochondria to reprogram the metabolism of M2-type macrophages for anti-tumor therapy 

Yonghui Wang et al.

Nanoscale. 2024 Nov 21;16(45):20925-20939. doi: 10.1039/d4nr02471k.

Published on October 29, 2024

M2-type macrophages (M2Φ) play a pro-tumorigenic role and are closely associated with tumor development, where metabolic dysregulation exacerbates the immunosuppressive tumor microenvironment and fosters tumor Read more

Glutaraldehyde-enhanced autofluorescence as a general tool for 3D morphological imaging 

Miika Niemeläinen et al.

Biol Open. 2024 Nov 15;13(11):bio060428. doi: 10.1242/bio.060428. Epub 2024 Nov 11.

Published on October 21, 2024

Routine histochemical techniques are capable of producing vast amount of information from diverse sample types, but these techniques are limited in their ability to generate Read more

Empirically establishing drug exposure records directly from untargeted metabolomics data 

Haoqi Nina Zhao et al.

bioRxiv [Preprint]. 2024 Oct 26:2024.10.07.617109. doi: 10.1101/2024.10.07.617109.

Published on October 17, 2024

Despite extensive efforts, extracting information on medication exposure from clinical records remains challenging. To complement this approach, we developed the tandem mass spectrometry (MS/MS) based Read more