Publications

Iron-doped nanozymes with spontaneous peroxidase-mimic activity as a promising antibacterial therapy for bacterial keratitis

Xiwen Geng et al.

Smart Med. 2024 May 22;3(2):e20240004. doi: 10.1002/SMMD.20240004. eCollection 2024 Jun.

The development of non-antibiotic pharmaceuticals with biocompatible and efficient antibacterial properties is of great significance for the treatment of bacterial keratitis. In this study, we have developed antibacterial iron-doped nanozymes (Fe^(3+)-doped nanozymes, FNEs) with distinguished capacity to fight against bacterial infections. The iron-doped nanozymes are composed of Fe^(3+) doped zeolitic imidazolate framework-8 (Fe/ZIF-8) and polyethylene imide (PEI), which were functionally...

Emerging ctDNA detection strategies in clinical cancer theranostics

Kexin Yi et al.

Smart Med. 2023 Nov 13;2(4):e20230031. doi: 10.1002/SMMD.20230031. eCollection 2023 Nov.

Circulating tumor DNA (ctDNA) is naked DNA molecules shed from the tumor cells into the peripheral blood circulation. They contain tumor-specific gene mutations and other valuable information. ctDNA is considered to be one of the most significant analytes in liquid biopsies. Over the past decades, numerous researchers have developed various detection strategies to perform quantitative or qualitative ctDNA analysis, including PCR-based detection and sequencing-based detection. More and more...

Novel coumarin-6-sulfonamide-chalcone hybrids as glutathione transferase P1-1 inhibitors

Ahmed Sabt et al.

PLoS One. 2024 Aug 14;19(8):e0306124. doi: 10.1371/journal.pone.0306124. eCollection 2024.

Multidrug resistance (MDR) mechanisms in cancer cells are greatly influenced by glutathione transferase P1-1 (hGSTP1-1). The use of synthetic or natural compounds as hGSTP1-1 inhibitors is considered an effective approach to overcome MDR. Nine compounds consisting of coumarin-6-sulfonamide linked to chalcone derivatives were synthesized and evaluated for their ability to inhibit hGSTP1-1. Among the synthetic derivatives, compounds 5g, 5f, and 5a displayed the most potent inhibitory effect, with...

CellTracksColab is a platform that enables compilation, analysis, and exploration of cell tracking data

Estibaliz Gómez-de-Mariscal et al.

PLoS Biol. 2024 Aug 8;22(8):e3002740. doi: 10.1371/journal.pbio.3002740. eCollection 2024 Aug.

In life sciences, tracking objects from movies enables researchers to quantify the behavior of single particles, organelles, bacteria, cells, and even whole animals. While numerous tools now allow automated tracking from video, a significant challenge persists in compiling, analyzing, and exploring the large datasets generated by these approaches. Here, we introduce CellTracksColab, a platform tailored to simplify the exploration and analysis of cell tracking data. CellTracksColab facilitates...

Utilizing Macrophages Missile for Sulfate-Based Nanomedicine Delivery in Lung Cancer Therapy

Chang Liu et al.

Research (Wash D C). 2024 Aug 6;7:0448. doi: 10.34133/research.0448. eCollection 2024.

Nanomaterial-based drug delivery systems are susceptible to premature drug leakage and systemic toxicity due to lack of specific targeting, and live-cell drug delivery is also prone to be restricted by drug carrier-cell interactions. Here, a method is established to adsorb drug-loaded nanomaterials externally to the live cells, which reduces cytotoxicity caused by drug uptake and improves the bioactivity of the carrier cells and drug release at the lesion site. It was found that polyphenols act...

Gene Regulatory Network Analysis of Decidual Stromal Cells and Natural Killer Cells

Kalle T Rytkönen et al.

Reprod Sci. 2024 Oct;31(10):3159-3174. doi: 10.1007/s43032-024-01653-1. Epub 2024 Aug 1.

Human reproductive success relies on the proper differentiation of the uterine endometrium to facilitate implantation, formation of the placenta, and pregnancy. This process involves two critical types of decidual uterine cells: endometrial/decidual stromal cells (dS) and uterine/decidual natural killer (dNK) cells. To better understand the transcription factors governing the in vivo functions of these cells, we analyzed single-cell transcriptomics data from first-trimester terminations of...