Publications

    Trajectories of microbiome-derived bile acids in early life – insights into the progression to islet autoimmunity 

    Santosh Lamichhane et al.

    medRxiv [Preprint]. 2025 Feb 24:2025.02.18.25322275. doi: 10.1101/2025.02.18.25322275.

    Published on March 10, 2025

    Recent studies reveal that gut microbes produce diverse bile acid conjugates, termed microbially conjugated bile acids (MCBAs). However, their regulation and health effects remain unclear. Read more

    Multifunctional Silk and Gelatin Composed Microneedle Patches for Enhanced Wound Healing 

    Lu Fan et al.

    Smart Med. 2025 Feb 26;4(1):e137. doi: 10.1002/smmd.137. eCollection 2025 Mar.

    Published on March 10, 2025

    Wound healing has been a continuous critical focus in clinical practice, posing the ongoing challenges and burdens to patients. Current attempts tend to develop multi-drug Read more

    Biomineralize Mitochondria in Metal-Organic Frameworks to Promote Mitochondria Transplantation From Non-Tumorigenic Cells Into Cancer Cells 

    Jun-Nian Zhou et al.

    Smart Med. 2025 Feb 26;4(1):e134. doi: 10.1002/smmd.134. eCollection 2025 Mar.

    Published on March 10, 2025

    Mitochondria are crucial to cellular physiology, and growing evidence highlights the significant impact of mitochondrial dysfunction in diabetes, aging, neurodegenerative disorders, and cancers. Therefore, mitochondrial Read more

    Risk of early death after treatment with curative intent for head and neck squamous cell carcinoma: a retrospective population-based study 

    Mahmoud Bazina et al.

    Acta Oncol. 2025 Mar 4;64:339-348. doi: 10.2340/1651-226X.2025.42202.

    Published on March 4, 2025

    BACKGROUND AND PURPOSE: Knowledge regarding the risk factors for early death in patients with head and neck squamous cell carcinoma (HNSCC) is scarce. This study Read more

    A new rapid lipoarabinomannan urine assay for tuberculosis: a two-centre diagnostic accuracy evaluation in outpatients with and without HIV 

    Beston Hamasur et al.

    Res Sq [Preprint]. 2025 Feb 18:rs.3.rs-5386988. doi: 10.21203/rs.3.rs-5386988/v2.

    Published on March 4, 2025

    CONCLUSIONS: BP-LAM has higher sensitivity than LF-LAM, including in HIV-negative people, potentially permitting the expansion of urine LAM testing beyond people with advanced immunosuppression.

    Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes affirms markers of disease 

    Robert Moulder et al.

    Diabetologia. 2025 Jun;68(6):1108-1114. doi: 10.1007/s00125-025-06394-7. Epub 2025 Feb 28.

    Published on February 28, 2025

    CONCLUSIONS/INTERPRETATION: The validated results reflect the landscape of biological changes accompanying type 1 diabetes. For example, the association of the targeted apolipoproteins with fasting C-peptide/glucose Read more

    Added value of HPV-DNA in situ hybridization as an adjunct to p16 Immunohistochemistry in oropharyngeal squamous cell carcinoma 

    Linda Nissi et al.

    Acta Otolaryngol. 2025 Apr;145(4):340-347. doi: 10.1080/00016489.2025.2461653. Epub 2025 Feb 10.

    Published on February 10, 2025

    CONCLUSIONS AND SIGNIFICANCE: Both p16 IHC and HPV-DNA ISH perform well as separate prognostic biomarkers for OS, DSS, and DFS on a population level. However, Read more

    Exploring the physicochemical interactions and loading strategies of mesoporous silicon dioxide nanoparticles for drug delivery 

    Svetlana Yu Kovtareva et al.

    Eur J Pharm Biopharm. 2025 Mar;208:114654. doi: 10.1016/j.ejpb.2025.114654. Epub 2025 Feb 3.

    Published on February 5, 2025

    Mesoporous silica nanoparticles play an important role in drug delivery due to their high surface area, porous structure, tunable pore size, chemical stability and functionalization Read more

    Nuclear talin-1 provides a bridge between cell adhesion and gene expression 

    Alejandro J Da Silva et al.

    iScience. 2025 Jan 4;28(2):111745. doi: 10.1016/j.isci.2025.111745. eCollection 2025 Feb 21.

    Published on February 3, 2025

    Talin-1 (TLN1) is best known to activate integrin receptors and transmit mechanical stimuli to the actin cytoskeleton at focal adhesions. However, the localization of TLN1 Read more

    Liquid and gas-chromatography-mass spectrometry methods for exposome analysis 

    Victor Castro-Alves et al.

    J Chromatogr A. 2025 Mar 15;1744:465728. doi: 10.1016/j.chroma.2025.465728. Epub 2025 Jan 25.

    Published on February 2, 2025

    Mass spectrometry-based methods have become fundamental to exposome research, providing the capability to explore a broad spectrum of chemical exposures. Liquid and gas chromatography coupled Read more

    Metaproteomics Beyond Databases: Addressing the Challenges and Potentials of De Novo Sequencing 

    Tim Van Den Bossche et al.

    Proteomics. 2025 Jan 31:e202400321. doi: 10.1002/pmic.202400321. Online ahead of print.

    Published on January 31, 2025

    Metaproteomics enables the large-scale characterization of microbial community proteins, offering crucial insights into their taxonomic composition, functional activities, and interactions within their environments. By directly Read more

    Adaptive sequence alignment for metagenomic data analysis 

    Sami Pietilä et al.

    Comput Biol Med. 2025 Mar;186:109743. doi: 10.1016/j.compbiomed.2025.109743. Epub 2025 Jan 26.

    Published on January 27, 2025

    With advances in sequencing technologies, the use of high-throughput sequencing to characterize microbial communities is becoming increasingly feasible. However, metagenomic assembly poses computational challenges in Read more