Publications

    PUBLICATION

    Structural Repetition Detector: multi-scale quantitative mapping of molecular complexes through microscopy 

    Afonso Mendes et al.

    Res Sq [Preprint]. 2024 Oct 15:rs.3.rs-5182329. doi: 10.21203/rs.3.rs-5182329/v1.

    Published on November 1, 2024

    From molecules to organelles, cells exhibit recurring structural motifs across multiple scales. Understanding these structures provides insights into their functional roles. While superresolution microscopy can Read more

    PUBLICATION

    Imaging cell architecture and dynamics 

    Lucy Collinson et al.

    J Cell Sci. 2024 Oct 15;137(20):jcs263575. doi: 10.1242/jcs.263575. Epub 2024 Oct 30.

    Published on October 30, 2024

    No abstract

    PUBLICATION

    Multiparameter imaging reveals clinically relevant cancer cell-stroma interaction dynamics in head and neck cancer 

    Karolina Punovuori et al.

    Cell. 2024 Dec 12;187(25):7267-7284.e20. doi: 10.1016/j.cell.2024.09.046. Epub 2024 Oct 28.

    Published on October 29, 2024

    Epithelial tumors are characterized by abundant inter- and intra-tumor heterogeneity, which complicates diagnostics and treatment. The contribution of cancer-stroma interactions to this heterogeneity is poorly Read more

    PUBLICATION

    Encapsulated mitochondria to reprogram the metabolism of M2-type macrophages for anti-tumor therapy 

    Yonghui Wang et al.

    Nanoscale. 2024 Nov 21;16(45):20925-20939. doi: 10.1039/d4nr02471k.

    Published on October 29, 2024

    M2-type macrophages (M2Φ) play a pro-tumorigenic role and are closely associated with tumor development, where metabolic dysregulation exacerbates the immunosuppressive tumor microenvironment and fosters tumor Read more

    PUBLICATION

    Glutaraldehyde-enhanced autofluorescence as a general tool for 3D morphological imaging 

    Miika Niemeläinen et al.

    Biol Open. 2024 Nov 15;13(11):bio060428. doi: 10.1242/bio.060428. Epub 2024 Nov 11.

    Published on October 21, 2024

    Routine histochemical techniques are capable of producing vast amount of information from diverse sample types, but these techniques are limited in their ability to generate Read more

    PUBLICATION

    Empirically establishing drug exposure records directly from untargeted metabolomics data 

    Haoqi Nina Zhao et al.

    bioRxiv [Preprint]. 2024 Oct 26:2024.10.07.617109. doi: 10.1101/2024.10.07.617109.

    Published on October 17, 2024

    Despite extensive efforts, extracting information on medication exposure from clinical records remains challenging. To complement this approach, we developed the tandem mass spectrometry (MS/MS) based Read more

    PUBLICATION

    Detection of Tn-antigen in breast and prostate cancer models by VVL-labeled red dye-doped nanoparticles 

    Alejandra Verhassel et al.

    Nanomedicine (Lond). 2024;19(29):2463-2478. doi: 10.1080/17435889.2024.2405454. Epub 2024 Oct 9.

    Published on October 9, 2024

    Aim: Fluorescence detection of breast and prostate cancer cells expressing Tn-antigen, a tumor marker, with Vicia villosa lectin (VVL)-labeled nanoparticles.Materials & methods: Breast and prostate Read more

    PUBLICATION

    Restoring mechanophenotype reverts malignant properties of ECM-enriched vocal fold cancer 

    Jasmin Kaivola et al.

    bioRxiv [Preprint]. 2024 Aug 23:2024.08.22.609159. doi: 10.1101/2024.08.22.609159.

    Published on October 7, 2024

    Increased extracellular matrix (ECM) and matrix stiffness promote solid tumor progression. However, mechanotransduction in cancers arising in mechanically active tissues remains underexplored. Here, we report Read more

    PUBLICATION

    Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards 

    Federico Torta et al.

    Nat Commun. 2024 Oct 3;15(1):8562. doi: 10.1038/s41467-024-52087-x.

    Published on October 3, 2024

    In this community effort, we compare measurements between 34 laboratories from 19 countries, utilizing mixtures of labelled authentic synthetic standards, to quantify by mass spectrometry Read more

    PUBLICATION

    The role and regulation of integrins in cell migration and invasion 

    Megan R Chastney et al.

    Nat Rev Mol Cell Biol. 2025 Feb;26(2):147-167. doi: 10.1038/s41580-024-00777-1. Epub 2024 Sep 30.

    Published on September 30, 2024

    Integrin receptors are the main molecular link between cells and the extracellular matrix (ECM) as well as mediating cell-cell interactions. Integrin-ECM binding triggers the formation Read more

    PUBLICATION

    Profiling steroid hormone landscape of bladder cancer reveals depletion of intratumoural androgens to castration levels: a cross-sectional study 

    Kimmo Kettunen et al.

    EBioMedicine. 2024 Oct;108:105359. doi: 10.1016/j.ebiom.2024.105359. Epub 2024 Sep 28.

    Published on September 29, 2024

    BACKGROUND: Bladder cancer is a highly over-represented disease in males. The involvement of sex steroids in bladder carcinogenesis and the utilisation of steroid hormone action Read more

    PUBLICATION

    Empagliflozin attenuates hypoxia-induced heart failure of zebrafish embryos via influencing MMP13 expression 

    R Huttunen et al.

    Biomed Pharmacother. 2024 Nov;180:117453. doi: 10.1016/j.biopha.2024.117453. Epub 2024 Sep 26.

    Published on September 27, 2024

    CONCLUSIONS: Our study shows that empagliflozin´s favorable effect on attenuating HF is mediated via MMP13. MMP13 provides a novel option when developing new therapeutics for Read more