Detection of Tn-antigen in breast and prostate cancer models by VVL-labeled red dye-doped nanoparticles 

Alejandra Verhassel et al.

Nanomedicine (Lond). 2024;19(29):2463-2478. doi: 10.1080/17435889.2024.2405454. Epub 2024 Oct 9.

Published on October 9, 2024

Aim: Fluorescence detection of breast and prostate cancer cells expressing Tn-antigen, a tumor marker, with Vicia villosa lectin (VVL)-labeled nanoparticles.Materials & methods: Breast and prostate Read more

Restoring mechanophenotype reverts malignant properties of ECM-enriched vocal fold cancer 

Jasmin Kaivola et al.

bioRxiv [Preprint]. 2024 Aug 23:2024.08.22.609159. doi: 10.1101/2024.08.22.609159.

Published on October 7, 2024

Increased extracellular matrix (ECM) and matrix stiffness promote solid tumor progression. However, mechanotransduction in cancers arising in mechanically active tissues remains underexplored. Here, we report Read more

Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards 

Federico Torta et al.

Nat Commun. 2024 Oct 3;15(1):8562. doi: 10.1038/s41467-024-52087-x.

Published on October 3, 2024

In this community effort, we compare measurements between 34 laboratories from 19 countries, utilizing mixtures of labelled authentic synthetic standards, to quantify by mass spectrometry Read more

The role and regulation of integrins in cell migration and invasion 

Megan R Chastney et al.

Nat Rev Mol Cell Biol. 2025 Feb;26(2):147-167. doi: 10.1038/s41580-024-00777-1. Epub 2024 Sep 30.

Published on September 30, 2024

Integrin receptors are the main molecular link between cells and the extracellular matrix (ECM) as well as mediating cell-cell interactions. Integrin-ECM binding triggers the formation Read more

Profiling steroid hormone landscape of bladder cancer reveals depletion of intratumoural androgens to castration levels: a cross-sectional study 

Kimmo Kettunen et al.

EBioMedicine. 2024 Oct;108:105359. doi: 10.1016/j.ebiom.2024.105359. Epub 2024 Sep 28.

Published on September 29, 2024

BACKGROUND: Bladder cancer is a highly over-represented disease in males. The involvement of sex steroids in bladder carcinogenesis and the utilisation of steroid hormone action Read more

Empagliflozin attenuates hypoxia-induced heart failure of zebrafish embryos via influencing MMP13 expression 

R Huttunen et al.

Biomed Pharmacother. 2024 Nov;180:117453. doi: 10.1016/j.biopha.2024.117453. Epub 2024 Sep 26.

Published on September 27, 2024

CONCLUSIONS: Our study shows that empagliflozin´s favorable effect on attenuating HF is mediated via MMP13. MMP13 provides a novel option when developing new therapeutics for Read more

IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis 

Peng Zhang et al.

Cell Metab. 2024 Oct 1;36(10):2341-2354.e6. doi: 10.1016/j.cmet.2024.08.012. Epub 2024 Sep 23.

Published on September 24, 2024

The exponential rise in metabolic dysfunction-associated steatotic liver disease (MASLD) parallels the ever-increasing consumption of energy-dense diets, underscoring the need for effective MASLD-resolving drugs. MASLD Read more

Atomistic simulations reveal impacts of missense mutations on the structure and function of SynGAP1 

Aliaa E Ali et al.

Brief Bioinform. 2024 Sep 23;25(6):bbae458. doi: 10.1093/bib/bbae458.

Published on September 23, 2024

De novo mutations in the synaptic GTPase activating protein (SynGAP) are associated with neurological disorders like intellectual disability, epilepsy, and autism. SynGAP is also implicated Read more

Single-cell transcriptome analysis of the early immune response in the lymph nodes of Borrelia burgdorferi-infected mice 

Varpu Rinne et al.

Microbes Infect. 2025 Feb;27(2):105424. doi: 10.1016/j.micinf.2024.105424. Epub 2024 Sep 19.

Published on September 21, 2024

Lyme borreliosis is a disease caused by Borrelia burgdorferi sensu lato bacteria. Borrelia burgdorferi is known to induce prolonged extrafollicular immune responses and abnormal germinal Read more

Proteomic profiling identifies a direct interaction between heat shock transcription factor 2 and the focal adhesion adapter talin-1 

Alejandro J Da Silva et al.

FEBS J. 2024 Nov;291(21):4830-4848. doi: 10.1111/febs.17271. Epub 2024 Sep 16.

Published on September 17, 2024

Heat shock factor 2 (HSF2) is a versatile transcription factor that regulates gene expression under stress conditions, during development, and in disease. Despite recent advances Read more

Heat stress sensitizes zebrafish embryos to neurological and cardiac toxicity 

Anna-Mari Haapanen-Saaristo et al.

Biochem Biophys Res Commun. 2024 Nov 12;733:150682. doi: 10.1016/j.bbrc.2024.150682. Epub 2024 Sep 10.

Published on September 14, 2024

Global warming increases the risk of dangerous heat waves, which may have deleterious effects on humans and wildlife. Here, we have utilized zebrafish embryos as Read more

SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers 

Johanna Lilja et al.

Nat Commun. 2024 Sep 12;15(1):8002. doi: 10.1038/s41467-024-52326-1.

Published on September 12, 2024

The KRAS oncogene drives many common and highly fatal malignancies. These include pancreatic, lung, and colorectal cancer, where various activating KRAS mutations have made the Read more