Publications

    PUBLICATION

    Surface Modification of Mesoporous Silica Nanoparticles as a Means to Introduce Inherent Cancer-Targeting Ability in a 3D Tumor Microenvironment 

    Neeraj Prabhakar et al.

    Small Sci. 2024 Jul 8;4(9):2400084. doi: 10.1002/smsc.202400084. eCollection 2024 Sep.

    Published on April 11, 2025

    Mesoporous silica nanoparticles (MSNs) have emerged as promising drug carriers that can facilitate targeted anticancer drug delivery, but efficiency studies relying on active targeting mechanisms Read more

    PUBLICATION

    mTORC1 shutdown unleashes TFEB to drive triple-negative breast cancer invasion 

    Michalis Gounis et al.

    Dev Cell. 2025 Apr 7;60(7):979-981. doi: 10.1016/j.devcel.2025.03.006.

    Published on April 8, 2025

    The PI3K/AKT/mTOR pathway is considered a key therapeutic target in triple-negative breast cancer (TNBC). In this issue of Developmental Cell, Remy et al. challenge this Read more

    PUBLICATION

    Practical considerations for data exploration in quantitative cell biology 

    Joanna W Pylvänäinen et al.

    J Cell Sci. 2025 Apr 1;138(7):jcs263801. doi: 10.1242/jcs.263801. Epub 2025 Apr 7.

    Published on April 7, 2025

    Data exploration is an essential step in quantitative cell biology, bridging raw data and scientific insights. Unlike polished, published figures, effective data exploration requires a Read more

    PUBLICATION

    Regulating macrophage glucose metabolism homeostasis via mitochondrial rheostats by short fiber-microsphere scaffolds for bone repair 

    Pengzhen Zhuang et al.

    Bioact Mater. 2025 Mar 15;49:399-417. doi: 10.1016/j.bioactmat.2025.03.008. eCollection 2025 Jul.

    Published on March 27, 2025

    The alterations in glucose metabolism flux induced by mitochondrial function changes are crucial for regulating bone immune homeostasis. The restoration of mitochondrial homeostasis, serving as Read more

    PUBLICATION

    Time, the final frontier 

    Gautier Follain et al.

    Mol Oncol. 2025 Mar 24. doi: 10.1002/1878-0261.70025. Online ahead of print.

    Published on March 24, 2025

    Cancer's notorious heterogeneity poses significant challenges, as each tumor comprises a unique ecosystem. While single-cell and spatial transcriptomics advancements have transformed our understanding of spatial Read more

    PUBLICATION

    Increased primary breast tumor expression of CD73 is associated with development of bone metastases and is a potential biomarker for adjuvant bisphosphonate use 

    Nataliia Petruk et al.

    Sci Rep. 2025 Mar 19;15(1):9449. doi: 10.1038/s41598-025-92841-9.

    Published on March 20, 2025

    CONCLUSIONS: High CD73 expression is associated with development of bone metastases. Zoledronate counteracts this effect. These results suggest that CD73 expression might serve as a Read more

    PUBLICATION

    Practical recommendations for developing software for life science applications 

    Joanna W Pylvänäinen et al.

    J Cell Sci. 2025 Mar 1;138(5):jcs263711. doi: 10.1242/jcs.263711. Epub 2025 Mar 17.

    Published on March 17, 2025

    Developing user-friendly image analysis software is essential for advancing biological and life science research. However, the interdisciplinary gap between software developers and life scientists presents Read more

    PUBLICATION

    Trajectories of microbiome-derived bile acids in early life – insights into the progression to islet autoimmunity 

    Santosh Lamichhane et al.

    medRxiv [Preprint]. 2025 Feb 24:2025.02.18.25322275. doi: 10.1101/2025.02.18.25322275.

    Published on March 10, 2025

    Recent studies reveal that gut microbes produce diverse bile acid conjugates, termed microbially conjugated bile acids (MCBAs). However, their regulation and health effects remain unclear. Read more

    PUBLICATION

    Multifunctional Silk and Gelatin Composed Microneedle Patches for Enhanced Wound Healing 

    Lu Fan et al.

    Smart Med. 2025 Feb 26;4(1):e137. doi: 10.1002/smmd.137. eCollection 2025 Mar.

    Published on March 10, 2025

    Wound healing has been a continuous critical focus in clinical practice, posing the ongoing challenges and burdens to patients. Current attempts tend to develop multi-drug Read more

    PUBLICATION

    Biomineralize Mitochondria in Metal-Organic Frameworks to Promote Mitochondria Transplantation From Non-Tumorigenic Cells Into Cancer Cells 

    Jun-Nian Zhou et al.

    Smart Med. 2025 Feb 26;4(1):e134. doi: 10.1002/smmd.134. eCollection 2025 Mar.

    Published on March 10, 2025

    Mitochondria are crucial to cellular physiology, and growing evidence highlights the significant impact of mitochondrial dysfunction in diabetes, aging, neurodegenerative disorders, and cancers. Therefore, mitochondrial Read more

    PUBLICATION

    Risk of early death after treatment with curative intent for head and neck squamous cell carcinoma: a retrospective population-based study 

    Mahmoud Bazina et al.

    Acta Oncol. 2025 Mar 4;64:339-348. doi: 10.2340/1651-226X.2025.42202.

    Published on March 4, 2025

    BACKGROUND AND PURPOSE: Knowledge regarding the risk factors for early death in patients with head and neck squamous cell carcinoma (HNSCC) is scarce. This study Read more

    PUBLICATION

    A new rapid lipoarabinomannan urine assay for tuberculosis: a two-centre diagnostic accuracy evaluation in outpatients with and without HIV 

    Beston Hamasur et al.

    Res Sq [Preprint]. 2025 Feb 18:rs.3.rs-5386988. doi: 10.21203/rs.3.rs-5386988/v2.

    Published on March 4, 2025

    CONCLUSIONS: BP-LAM has higher sensitivity than LF-LAM, including in HIV-negative people, potentially permitting the expansion of urine LAM testing beyond people with advanced immunosuppression.