Publications

    PUBLICATION

    Nuclear talin-1 provides a bridge between cell adhesion and gene expression 

    Alejandro J Da Silva et al.

    iScience. 2025 Jan 4;28(2):111745. doi: 10.1016/j.isci.2025.111745. eCollection 2025 Feb 21.

    Published on February 3, 2025

    Talin-1 (TLN1) is best known to activate integrin receptors and transmit mechanical stimuli to the actin cytoskeleton at focal adhesions. However, the localization of TLN1 Read more

    PUBLICATION

    Liquid and gas-chromatography-mass spectrometry methods for exposome analysis 

    Victor Castro-Alves et al.

    J Chromatogr A. 2025 Mar 15;1744:465728. doi: 10.1016/j.chroma.2025.465728. Epub 2025 Jan 25.

    Published on February 2, 2025

    Mass spectrometry-based methods have become fundamental to exposome research, providing the capability to explore a broad spectrum of chemical exposures. Liquid and gas chromatography coupled Read more

    PUBLICATION

    Metaproteomics Beyond Databases: Addressing the Challenges and Potentials of De Novo Sequencing 

    Tim Van Den Bossche et al.

    Proteomics. 2025 Jan 31:e202400321. doi: 10.1002/pmic.202400321. Online ahead of print.

    Published on January 31, 2025

    Metaproteomics enables the large-scale characterization of microbial community proteins, offering crucial insights into their taxonomic composition, functional activities, and interactions within their environments. By directly Read more

    PUBLICATION

    Adaptive sequence alignment for metagenomic data analysis 

    Sami Pietilä et al.

    Comput Biol Med. 2025 Mar;186:109743. doi: 10.1016/j.compbiomed.2025.109743. Epub 2025 Jan 26.

    Published on January 27, 2025

    With advances in sequencing technologies, the use of high-throughput sequencing to characterize microbial communities is becoming increasingly feasible. However, metagenomic assembly poses computational challenges in Read more

    PUBLICATION

    Dual physiological responsive structural color hydrogel particles for wound repair 

    Li Wang et al.

    Bioact Mater. 2025 Jan 7;46:494-502. doi: 10.1016/j.bioactmat.2025.01.002. eCollection 2025 Apr.

    Published on January 27, 2025

    Hydrogel-based patches have demonstrated their values in diabetic wounds repair, particularly those intelligent dressings with continuous repair promoting and monitoring capabilities. Here, we propose a Read more

    PUBLICATION

    Mechanically regulated microcarriers with stem cell loading for skin photoaging therapy 

    Xiang Lin et al.

    Bioact Mater. 2025 Jan 3;46:448-456. doi: 10.1016/j.bioactmat.2024.12.024. eCollection 2025 Apr.

    Published on January 24, 2025

    Long-term exposure to ultraviolet radiation compromises skin structural integrity and results in disruption of normal physiological functions. Stem cells have gained attention in anti-photoaging, while Read more

    PUBLICATION

    Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance 

    Henna Lehtonen et al.

    Cell Rep. 2025 Feb 25;44(2):115227. doi: 10.1016/j.celrep.2024.115227. Epub 2025 Jan 21.

    Published on January 22, 2025

    The pituitary gland is the central endocrine regulatory organ producing and releasing hormones that coordinate major body functions. The physical location of the pituitary gland Read more

    PUBLICATION

    Microfluidics-enabled core/shell nanostructure assembly: Understanding encapsulation processes via particle characterization and molecular dynamics 

    Wali Inam et al.

    Adv Colloid Interface Sci. 2025 Apr;338:103400. doi: 10.1016/j.cis.2025.103400. Epub 2025 Jan 12.

    Published on January 17, 2025

    In the realm of hybrid nanomaterials, the construction of core/shell nanoparticles offer an effective strategy for encompassing a particle by a polymeric or other suitable Read more

    PUBLICATION

    There Goes the Neighbourhood-A Multi-City Study Reveals Ticks and Tick-Borne Pathogens Commonly Occupy Urban Green Spaces 

    Jani J Sormunen et al.

    Zoonoses Public Health. 2025 May;72(3):313-323. doi: 10.1111/zph.13208. Epub 2025 Jan 16.

    Published on January 17, 2025

    CONCLUSIONS: Ticks and TBPs are commonplace in urban green spaces in Finland. Enzootic cycles for Borrelia and Rickettsia appear to be well maintained within cities, Read more

    PUBLICATION

    Proteomic profiling reveals alterations in metabolic and cellular pathways in severe obesity and following metabolic bariatric surgery 

    Prince Dadson et al.

    Am J Physiol Endocrinol Metab. 2025 Mar 1;328(3):E311-E324. doi: 10.1152/ajpendo.00220.2024. Epub 2025 Jan 17.

    Published on January 17, 2025

    In this study, we investigated the impact of bariatric surgery on the adipose proteome to better understand the metabolic and cellular mechanisms underlying weight loss Read more

    PUBLICATION

    Efficiently accelerated bioimage analysis with NanoPyx, a Liquid Engine-powered Python framework 

    Bruno M Saraiva et al.

    Nat Methods. 2025 Feb;22(2):283-286. doi: 10.1038/s41592-024-02562-6. Epub 2025 Jan 2.

    Published on January 2, 2025

    The expanding scale and complexity of microscopy image datasets require accelerated analytical workflows. NanoPyx meets this need through an adaptive framework enhanced for high-speed analysis. Read more

    PUBLICATION

    Harnessing artificial intelligence to reduce phototoxicity in live imaging 

    J Cell Sci. 2024 Feb 1;137(3):jcs261545. doi: 10.1242/jcs.261545. Epub 2024 Feb 7.

    Fluorescence microscopy is essential for studying living cells, tissues and organisms. However, the fluorescent light that switches on fluorescent molecules also harms the samples, jeopardizing the validity of results - particularly in techniques such as super-resolution microscopy, which demands extended illumination. Artificial intelligence (AI)-enabled software capable of denoising, image restoration, temporal interpolation or cross-modal style transfer has great potential to rescue live imaging data and limit photodamage. Yet we believe the focus should be on maintaining light-induced damage at levels that preserve natural cell behaviour. In this Opinion piece, we argue that a shift in role for AIs is needed - AI should be used to extract rich insights from gentle imaging rather than recover compromised data from harsh illumination. Although AI can enhance imaging, our ultimate goal should be to uncover biological truths, not just retrieve data. It is essential to prioritize minimizing photodamage over merely pushing technical limits. Our approach is aimed towards gentle acquisition and observation of undisturbed living systems, aligning with the essence of live-cell fluorescence microscopy.

    Published on December 27, 2024

    Fluorescence microscopy is essential for studying living cells, tissues and organisms. However, the fluorescent light that switches on fluorescent molecules also harms the samples, jeopardizing Read more