Phenotypic profiling of human induced regulatory T cells at early differentiation: insights into distinct immunosuppressive potential 

Roosa Kattelus et al.

Cell Mol Life Sci. 2024 Sep 12;81(1):399. doi: 10.1007/s00018-024-05429-3.

Published on September 12, 2024

Regulatory T cells (Tregs) play a key role in suppressing systemic effector immune responses, thereby preventing autoimmune diseases but also potentially contributing to tumor progression. Read more

Comparative proteomics analysis of the mouse mini-gut organoid: insights into markers of gluten challenge from celiac disease intestinal biopsies 

Robert Moulder et al.

Front Mol Biosci. 2024 Aug 28;11:1446822. doi: 10.3389/fmolb.2024.1446822. eCollection 2024.

Published on September 12, 2024

INTRODUCTION: Organoid models enable three-dimensional representation of cellular systems, providing flexible and accessible research tools, and can highlight key biomolecules. Such models of the intestinal Read more

Hypoxia and Foxn1 alter the proteomic signature of dermal fibroblasts to redirect scarless wound healing to scar-forming skin wound healing in Foxn1-/- mice 

Barbara Gawronska-Kozak et al.

BMC Biol. 2024 Sep 11;22(1):193. doi: 10.1186/s12915-024-01990-2.

Published on September 10, 2024

CONCLUSIONS: The present data highlight the effect of hypoxia and Foxn1 on the protein profile and functionality of regenerative Foxn1^(-/-) DFs and demonstrate that the Read more

Serum lipidome associates with neuroimaging features in patients with traumatic brain injury 

Ilias Thomas et al.

iScience. 2024 Aug 3;27(9):110654. doi: 10.1016/j.isci.2024.110654. eCollection 2024 Sep 20.

Published on September 10, 2024

Acute traumatic brain injury (TBI) is associated with substantial abnormalities in lipid biology, including changes in the structural lipids that are present in the myelin Read more

Disruption of HSD17B12 in mouse hepatocytes leads to reduced body weight and defect in the lipid droplet expansion associated with microvesicular steatosis 

Hanna Heikelä et al.

FASEB J. 2024 Sep 15;38(17):e70034. doi: 10.1096/fj.202400333RR.

Published on September 9, 2024

The function of hydroxysteroid dehydrogenase 12 (HSD17B12) in lipid metabolism is poorly understood. To study this further, we created mice with hepatocyte-specific knockout of HSD17B12 Read more

Lower Plasma Levels of Selective VGF (Non-Acronymic) Peptides in Bipolar Disorder: Comparative Analysis Reveals Distinct Patterns across Mood Disorders and Healthy Controls 

Cristina Cocco et al.

Neuropsychobiology. 2024;83(3-4):160-169. doi: 10.1159/000540673. Epub 2024 Sep 6.

Published on September 8, 2024

CONCLUSION: Our findings suggest that lower plasma levels of NAPP and AQEE are specifically associated with BD, thus possibly representing a diagnostic biomarker in mood Read more

ECCB2024: The 23rd European Conference on Computational Biology 

Anu Kukkonen-Macchi et al.

Bioinformatics. 2024 Sep 1;40(Suppl 2):ii1-ii3. doi: 10.1093/bioinformatics/btae422.

Published on September 4, 2024

No abstract

Intermediate filaments at a glance 

Leila S Coelho-Rato et al.

J Cell Sci. 2024 Aug 15;137(16):jcs261386. doi: 10.1242/jcs.261386. Epub 2024 Aug 29.

Published on August 29, 2024

Intermediate filaments (IFs) comprise a large family of versatile cytoskeletal proteins, divided into six subtypes with tissue-specific expression patterns. IFs have a wide repertoire of Read more

Iron-doped nanozymes with spontaneous peroxidase-mimic activity as a promising antibacterial therapy for bacterial keratitis 

Xiwen Geng et al.

Smart Med. 2024 May 22;3(2):e20240004. doi: 10.1002/SMMD.20240004. eCollection 2024 Jun.

Published on August 27, 2024

The development of non-antibiotic pharmaceuticals with biocompatible and efficient antibacterial properties is of great significance for the treatment of bacterial keratitis. In this study, we Read more

Emerging ctDNA detection strategies in clinical cancer theranostics 

Kexin Yi et al.

Smart Med. 2023 Nov 13;2(4):e20230031. doi: 10.1002/SMMD.20230031. eCollection 2023 Nov.

Published on August 27, 2024

Circulating tumor DNA (ctDNA) is naked DNA molecules shed from the tumor cells into the peripheral blood circulation. They contain tumor-specific gene mutations and other Read more

Novel coumarin-6-sulfonamide-chalcone hybrids as glutathione transferase P1-1 inhibitors 

Ahmed Sabt et al.

PLoS One. 2024 Aug 14;19(8):e0306124. doi: 10.1371/journal.pone.0306124. eCollection 2024.

Published on August 14, 2024

Multidrug resistance (MDR) mechanisms in cancer cells are greatly influenced by glutathione transferase P1-1 (hGSTP1-1). The use of synthetic or natural compounds as hGSTP1-1 inhibitors Read more

CellTracksColab is a platform that enables compilation, analysis, and exploration of cell tracking data 

Estibaliz Gómez-de-Mariscal et al.

PLoS Biol. 2024 Aug 8;22(8):e3002740. doi: 10.1371/journal.pbio.3002740. eCollection 2024 Aug.

Published on August 8, 2024

In life sciences, tracking objects from movies enables researchers to quantify the behavior of single particles, organelles, bacteria, cells, and even whole animals. While numerous Read more