Publications

    Novel coumarin-6-sulfonamide-chalcone hybrids as glutathione transferase P1-1 inhibitors 

    Ahmed Sabt et al.

    PLoS One. 2024 Aug 14;19(8):e0306124. doi: 10.1371/journal.pone.0306124. eCollection 2024.

    Published on August 14, 2024

    Multidrug resistance (MDR) mechanisms in cancer cells are greatly influenced by glutathione transferase P1-1 (hGSTP1-1). The use of synthetic or natural compounds as hGSTP1-1 inhibitors Read more

    CellTracksColab is a platform that enables compilation, analysis, and exploration of cell tracking data 

    Estibaliz Gómez-de-Mariscal et al.

    PLoS Biol. 2024 Aug 8;22(8):e3002740. doi: 10.1371/journal.pbio.3002740. eCollection 2024 Aug.

    Published on August 8, 2024

    In life sciences, tracking objects from movies enables researchers to quantify the behavior of single particles, organelles, bacteria, cells, and even whole animals. While numerous Read more

    Utilizing Macrophages Missile for Sulfate-Based Nanomedicine Delivery in Lung Cancer Therapy 

    Chang Liu et al.

    Research (Wash D C). 2024 Aug 6;7:0448. doi: 10.34133/research.0448. eCollection 2024.

    Published on August 7, 2024

    Nanomaterial-based drug delivery systems are susceptible to premature drug leakage and systemic toxicity due to lack of specific targeting, and live-cell drug delivery is also Read more

    Synaptic proteome perturbations after maternal immune activation: Identification of embryonic and adult hippocampal changes 

    Anna Y Yotova et al.

    Brain Behav Immun. 2024 Oct;121:351-364. doi: 10.1016/j.bbi.2024.07.040. Epub 2024 Jul 31.

    Published on August 1, 2024

    CONCLUSIONS: Our data emphasise the dynamic effects of viral-like MIA on developing and mature hippocampi and provide novel targets for study following prenatal immune challenges. Read more

    Gene Regulatory Network Analysis of Decidual Stromal Cells and Natural Killer Cells 

    Kalle T Rytkönen et al.

    Reprod Sci. 2024 Oct;31(10):3159-3174. doi: 10.1007/s43032-024-01653-1. Epub 2024 Aug 1.

    Published on August 1, 2024

    Human reproductive success relies on the proper differentiation of the uterine endometrium to facilitate implantation, formation of the placenta, and pregnancy. This process involves two Read more

    Inferring Tree-Shaped Single-Cell Trajectories with Totem 

    António G G Sousa et al.

    Methods Mol Biol. 2024;2812:169-191. doi: 10.1007/978-1-0716-3886-6_9.

    Published on July 27, 2024

    Single-cell transcriptomics allows unbiased characterization of cell heterogeneity in a sample by profiling gene expression at single-cell level. These profiles capture snapshots of transient or Read more

    HSV-1 and Cellular miRNAs in CSF-Derived Exosomes as Diagnostically Relevant Biomarkers for Neuroinflammation 

    Christian Scheiber et al.

    Cells. 2024 Jul 17;13(14):1208. doi: 10.3390/cells13141208.

    Published on July 26, 2024

    Virus-associated chronic inflammation may contribute to autoimmunity in a number of diseases. In the brain, autoimmune encephalitis appears related to fluctuating reactivation states of neurotropic Read more

    The PP2A regulator IER5L supports prostate cancer progression 

    Jana R Crespo et al.

    Cell Death Dis. 2024 Jul 18;15(7):514. doi: 10.1038/s41419-024-06907-z.

    Published on July 18, 2024

    Prostate cancer exhibits high prevalence and accounts for a high number of cancer-related deaths. The discovery and characterization of molecular determinants of aggressive prostate cancer Read more

    Protocol to study early lung developmental branching in mouse embryos using explant culture 

    Salli Talvi et al.

    STAR Protoc. 2024 Sep 20;5(3):103198. doi: 10.1016/j.xpro.2024.103198. Epub 2024 Jul 17.

    Published on July 18, 2024

    Mouse lung branching morphogenesis creates epithelial tree structures required for respiration. Here, we present a protocol for studying mouse lung developmental branching using lung explant Read more

    TLNRD1 is a CCM complex component and regulates endothelial barrier integrity 

    Neil J Ball et al.

    J Cell Biol. 2024 Sep 2;223(9):e202310030. doi: 10.1083/jcb.202310030. Epub 2024 Jul 16.

    Published on July 16, 2024

    We previously identified talin rod domain-containing protein 1 (TLNRD1) as a potent actin-bundling protein in vitro. Here, we report that TLNRD1 is expressed in the Read more

    Identification of an H-Ras nanocluster disrupting peptide 

    Candy Laura Steffen et al.

    Commun Biol. 2024 Jul 9;7(1):837. doi: 10.1038/s42003-024-06523-9.

    Published on July 9, 2024

    Hyperactive Ras signalling is found in most cancers. Ras proteins are only active in membrane nanoclusters, which are therefore potential drug targets. We previously showed Read more

    Body-wide genetic deficiency of poly(ADP-ribose) polymerase 14 sensitizes mice to colitis 

    Madhukar Vedantham et al.

    FASEB J. 2024 Jul 15;38(13):e23775. doi: 10.1096/fj.202400484R.

    Published on July 5, 2024

    Inflammatory bowel disease (IBD) is a chronic disease of the gastrointestinal tract affecting millions of people. Here, we investigated the expression and functions of poly(ADP-ribose) Read more